N-[3-[bis(2-chloroethyl)aminomethyl]-4-methoxyphenyl]-7-chloroquinolin-4-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-[3-[bis(2-chloroethyl)aminomethyl]-4-methoxyphenyl]-7-chloroquinolin-4-amine
• 化学式: C₂₁H₂₂Cl₃N₃O
• 分子量: 438.8
• InChiKey: HFGLFYWVOHGDPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  37.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• TREATING FLAVIVIRUS INFECTIONS WITH AMODIAQUINE AND DERIVATIVES THEREOF
  申请人：Nagarajan Kuppuswamy

  公开号：US20170165254A1

  公开（公告）日：2017-06-15

  Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a Flavivirus inhibitor. These methods are useful in treating, preventing, and/or ameliorating Flavivirus infections such as, for example, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus.
• [EN] TREATING FLAVIVIRUS INFECTIONS WITH AMODIAQUINE AND DERIVATIVES THEREOF<br/>[FR] TRAITEMENT D'INFECTIONS PAR UN FLAVIVIRUS AVEC DE L'AMODIAQUINE ET SES DÉRIVÉS
  申请人：UNIV GEORGETOWN

  公开号：WO2015120127A2

  公开（公告）日：2015-08-13

  Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a Flavivirus inhibitor. These methods are useful in treating, preventing, and/or ameliorating Flavivirus infections such as, for example, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus.