2-[[1-(2,5-dimethylphenyl)ethyl]thio]-4-methylquinoline | 478620-38-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-[[1-(2,5-dimethylphenyl)ethyl]thio]-4-methylquinoline
• 英文别名: 2-[1-(2,5-Dimethylphenyl)ethylsulfanyl]-4-methyl-quinoline；2-[1-(2,5-dimethylphenyl)ethylsulfanyl]-4-methylquinoline
• CAS: 478620-38-1
• 化学式: C₂₀H₂₁NS
• 分子量: 307.459
• InChiKey: LAFFJYCRWZMNTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  38.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-thiol-4-methylquinoline 、 2,5-dimethylphenyl(2-bromoethyl)benzene 生成 2-[[1-(2,5-dimethylphenyl)ethyl]thio]-4-methylquinoline
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Method for treating retroviral infections
  申请人：——

  公开号：US20030139445A1

  公开（公告）日：2003-07-24

  Compositions and methods of treating a retroviral infection in an afflicted host and/or inhibiting replication of a retrovirus involve administering a therapeutically effective amount of the following compound of formula I: A—L—B  (I) wherein A is a substituted or unsubstituted aryl compound, substituted or unsubstituted piperidyl, or substituted or unsubstituted thiopheneyl; L is sulfonyl, sulfinyl or thio; and B is a substituted or unsubstituted aromatic nitrogen containing heteroaryl compound; or pharmacologically acceptable acid-addition and base-addition salts thereof.

  治疗受感染宿主的逆转录病毒感染和/或抑制逆转录病毒复制的组合物和方法涉及向患者施用以下化合物的治疗有效量，该化合物的化学式为：A—L—B（I），其中A是取代或未取代的芳基化合物、取代或未取代的哌啶基或取代或未取代的噻吩基；L是磺酰基、亚砜基或硫；B是取代或未取代的含芳香族氮的杂环化合物；或其药理学可接受的酸盐和碱盐添加物。
• US6498254B1
  申请人：——

  公开号：US6498254B1

  公开（公告）日：2002-12-24
• US7064139B2
  申请人：——

  公开号：US7064139B2

  公开（公告）日：2006-06-20
• [EN] METHOD FOR TREATING RETROVIRAL INFECTIONS<br/>[FR] METHODE DE TRAITEMENT D'INFECTIONS RETROVIRALES
  申请人：UNIROYAL CHEM CO INC

  公开号：WO2003037311A2

  公开（公告）日：2003-05-08

  Compositions and methods of treating a retroviral infection in an afflicted host and/or inhibiting replication of a retrovirus involve administering a therapeutically effective amount of the following compound of formula (I): wherein A is a substituted or unsubstituted aryl compound, substituted or unsubstituted piperidyl, or substituted or unsubstituted thiopheneyl; L is sulfonyl, sulfinyl or thio; and B is a substituted or unsubstituted aromatic nitrogen containing heteroaryl compound; or pharmacologically acceptable acid-addition and base-addition salts thereof.
• [EN] ANTIRETROVIRAL PYRIDINE AND QUINOLINE DERIVATIVES<br/>[FR] DERIVES DE PYRIDINE ET DE QUINOLINE ANTIRETROVIRAUX
  申请人：UNIROYAL CHEM CO INC

  公开号：WO2003037866A1

  公开（公告）日：2003-05-08

  Certain pyridine and quinoline derivatives which inhibit replication of the retroviruses HIV-1, HIV-2 and human cytomegalovirus (HCMV) are provided. Pharmaceutical compositions useful in methods of treating or inhibiting certain retrovirus infections are described.