1-(2-isopropoxy-6-isopropenylphenyl)ethanone | 1116113-33-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2-isopropoxy-6-isopropenylphenyl)ethanone
• 英文别名: 1-(2-Propan-2-yloxy-6-prop-1-en-2-ylphenyl)ethanone；1-(2-propan-2-yloxy-6-prop-1-en-2-ylphenyl)ethanone
• CAS: 1116113-33-7
• 化学式: C₁₄H₁₈O₂
• 分子量: 218.296
• InChiKey: ODFITBNKLKELHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(2-异丙氧基苯基)乙酮 、 2-isopropenyl-5,5-dimethyl-[1,3,2]dioxaborinane 在 频哪酮 、 C₅₅H₅₀O₃P₂Ru 作用下， 反应 20.0h， 以91%的产率得到1-(2-isopropoxy-6-isopropenylphenyl)ethanone
  参考文献：
  名称：

  Unique Effect of Coordination of an Alkene Moiety in Products on Ruthenium-Catalyzed Chemoselective C−H Alkenylation

  摘要：

  Ruthenium-catalyzed alkenylation of 2'-alkoxyacetophenones with alkenylboronates provides ortho C-H alkenylation products without sacrificing an ether functional group at the other ortho position. Both excellent chemoselectivity and high product yields are achieved with an aryloxo ruthenium complex. The effective suppression of the C-O bond cleavage was attained by coordination of the alkenyl moiety in the C-H alkenylation product to the ruthenium center.

  DOI：

  10.1021/ol802819b

文献信息

• Unique Effect of Coordination of an Alkene Moiety in Products on Ruthenium-Catalyzed Chemoselective C−H Alkenylation
  作者：Satoshi Ueno、Takuya Kochi、Naoto Chatani、Fumitoshi Kakiuchi

  DOI：10.1021/ol802819b

  日期：2009.2.19

  Ruthenium-catalyzed alkenylation of 2'-alkoxyacetophenones with alkenylboronates provides ortho C-H alkenylation products without sacrificing an ether functional group at the other ortho position. Both excellent chemoselectivity and high product yields are achieved with an aryloxo ruthenium complex. The effective suppression of the C-O bond cleavage was attained by coordination of the alkenyl moiety in the C-H alkenylation product to the ruthenium center.