[(E)-4-(4-methoxyphenyl)-2-oxobut-3-enyl] 4-methylbenzenesulfonate | 1252574-76-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: [(E)-4-(4-methoxyphenyl)-2-oxobut-3-enyl] 4-methylbenzenesulfonate
• CAS: 1252574-76-7
• 化学式: C₁₈H₁₈O₅S
• 分子量: 346.404
• InChiKey: GJZCVRMKENJXDM-VMPITWQZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  78
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  [(E)-4-(4-methoxyphenyl)-2-oxobut-3-enyl] 4-methylbenzenesulfonate 、 硫脲 以 乙醇 为溶剂， 以65%的产率得到(E)-4-(4-methoxystyryl)thiazol-2-amine
  参考文献：
  名称：

  HTIB-Mediated One-Pot Synthesis of Some 2-Substituted 4-Styrylthiazoles from (E)-4-Arylbut-3-en-2-ones

  摘要：

  The reaction of (E)-4-arylbut-3-en-2-ones with [(hydroxy(tosyloxy)iodo]benzene (HTIB) followed by treatment with thioureas, thioamide, and thiobenzamide has offered a one-pot synthesis of 2-substituted 4-styrylthiazoles.Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental file.

  DOI：

  10.1080/00397911.2011.604815
• 作为产物：
  描述：

  羟基甲苯磺酰碘苯 、 反-4-(4-甲氧苯基)-3-丁烯-2-酮 以 二氯甲烷 为溶剂， 生成 [(E)-4-(4-methoxyphenyl)-2-oxobut-3-enyl] 4-methylbenzenesulfonate
  参考文献：
  名称：

  HTIB-Mediated One-Pot Synthesis of Some 2-Substituted 4-Styrylthiazoles from (E)-4-Arylbut-3-en-2-ones

  摘要：

  The reaction of (E)-4-arylbut-3-en-2-ones with [(hydroxy(tosyloxy)iodo]benzene (HTIB) followed by treatment with thioureas, thioamide, and thiobenzamide has offered a one-pot synthesis of 2-substituted 4-styrylthiazoles.Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental file.

  DOI：

  10.1080/00397911.2011.604815

文献信息

• HTIB-Mediated One-Pot Synthesis of Some 2-Substituted 4-Styrylthiazoles from (<i>E</i>)-4-Arylbut-3-en-2-ones
  作者：Om Prakash、Nitya Sharma、Pooja Ranjan

  DOI：10.1080/00397911.2011.604815

  日期：2013.1.1

  The reaction of (E)-4-arylbut-3-en-2-ones with [(hydroxy(tosyloxy)iodo]benzene (HTIB) followed by treatment with thioureas, thioamide, and thiobenzamide has offered a one-pot synthesis of 2-substituted 4-styrylthiazoles.Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental file.