2-(1-Hydroxybenzyl)cyclohexanol | 83915-68-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(1-Hydroxybenzyl)cyclohexanol
• 英文别名: 2-(hydroxy-phenyl-methyl)-cyclohexanol；2-(hydroxy-phenyI-methyl)-cyclohexanol；2-(Hydroxyphenylmethyl)cyclohexanol；2-[hydroxy(phenyl)methyl]cyclohexan-1-ol
• CAS: 83915-68-8
• 化学式: C₁₃H₁₈O₂
• 分子量: 206.285
• InChiKey: CJBGXBKIDRIJOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  trans-2-[1-(Phenylseleno)benzyl]cyclohexanol 在 双氧水 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 以71%的产率得到2-(1-Hydroxybenzyl)cyclohexanol
  参考文献：
  名称：

  Oxidation of alcohols with dimethyl selenide-N-chlorosuccinimide complex

  摘要：

  DOI：

  10.1021/jo00149a011

文献信息

• New bicyclic dioxanes, their preparation and their use as organoleptic compounds
  申请人：V.Mane Fils

  公开号：EP2287159A1

  公开（公告）日：2011-02-23

  The present invention relates to novel 1,3-dioxane derivatives of formula (I) wherein each of R1 and R2 is a hydrogen atom, R3 and R4 are independently a hydrogen atom, a linear or branched C1-C6 alkyl group, or a linear or branched C2-C6 alkenyl group, and R5 is a linear or branched C1-C6 alkyl group, a linear or branched C2-C6 alkenyl group or a (CH2)0-2 - aryl group, and R6 and R7 are independently a hydrogen atom, a linear or branched C1-C6 alkyl group, a linear or branched C2-C6 alkenyl group or a (CH2)0-2 - aryl group, or R6 and R7 together with the carbon atom to which they are attached form a C5-C6 cycloalkyl group or a C5-C6 cycloalkenyl group, substituted or not; their preparation and their use as organoleptic compounds.

  本发明涉及新颖的1,3-二噁烷衍生物，其化学式为（I），其中R1和R2中的每个都是氢原子，R3和R4分别是氢原子、直链或支链的C1-C6烷基基团，或直链或支链的C2-C6烯基基团，R5是直链或支链的C1-C6烷基基团、直链或支链的C2-C6烯基基团或（CH2）0-2芳基基团，R6和R7分别是氢原子、直链或支链的C1-C6烷基基团、直链或支链的C2-C6烯基基团或（CH2）0-2芳基基团，或者R6和R7与它们连接的碳原子一起形成取代或非取代的C5-C6环烷基基团或C5-C6环烯基基团；它们的制备及其用作感官化合物。
• [EN] NEW BICYCLIC DIOXANES, THEIR PREPARATION AND THEIR USE AS FRAGRANT COMPOUNDS<br/>[FR] NOUVEAUX DIOXANES BICYCLIQUES, LEUR PRÉPARATION ET LEUR UTILISATION EN TANT QUE COMPOSÉS DE PARFUM
  申请人：MANE FILS V

  公开号：WO2011013077A1

  公开（公告）日：2011-02-03

  The invention is directed to the use of compounds of formula (I), as fragrant agents. In this formula: - R3 and R4 are independently a hydrogen atom, a C1-C6 alkyl group or a C2-C6 alkenyl group, R5 is a C1-C6 alkyl group, a C2-C6 alkenyl group or a (CH2)0-2-aryl group, R6 is a C1 -C6 alkyl group, a C2-C6 alkenyl group, a (CH2)0-2-aryl group or a C5- C6 cycloalkyl or cycloalkenyl group, and R7 is a hydrogen atom, a C1-C6 alkyl group or a C2-C6 alkenyl group; or R3, R4 and R5 are as above defined, and R6 and R7 together with the carbon atom to which they are attached form a C5-C6 cycloalkyl or cycloalkenyl group.

  该发明涉及使用式（I）的化合物作为香料剂。在这个式子中：- R3和R4独立地是氢原子，C1-C6烷基或C2-C6烯基，R5是C1-C6烷基，C2-C6烯基或（CH2）0-2-芳基，R6是C1-C6烷基，C2-C6烯基，（CH2）0-2-芳基或C5-C6环烷基或环烯基，R7是氢原子，C1-C6烷基或C2-C6烯基；或者R3，R4和R5如上定义，R6和R7与它们连接的碳原子一起形成C5-C6环烷基或环烯基。
• New Bicyclic Dioxanes, Their Preparation and Their Use as Fragrant Compounds
  申请人：Chanot Jean-Jacques

  公开号：US20120165557A1

  公开（公告）日：2012-06-28

  The invention is directed to the use of compounds of formula (I), as fragrant agents. In this formula: —R 3 and R 4 are independently a hydrogen atom, a C1-C6 alkyl group or a C2-C6 alkenyl group, R 5 is a C1-C6 alkyl group, a C2-C6 alkenyl group or a (CH2) 0-2 -aryl group, R 6 is a C1-C6 alkyl group, a C2-C6 alkenyl group, a (CH2) 0-2 -aryl group or a C5-C6 cycloalkyl or cycloalkenyl group, and R 7 is a hydrogen atom, a C1-C6 alkyl group or a C2-C6 alkenyl group; or R 3 , R 4 and R 5 are as above defined, and R 6 and R 7 together with the carbon atom to which they are attached form a C5-C6 cycloalkyl or cycloalkenyl group.

  本发明涉及使用式（I）化合物作为香味剂。在此式中：—R3和R4独立地是氢原子、C1-C6烷基或C2-C6烯基基团，R5是C1-C6烷基、C2-C6烯基或（CH2）0-2芳基基团，R6是C1-C6烷基、C2-C6烯基、（CH2）0-2芳基基团或C5-C6环烷基或环烯基基团，而R7是氢原子、C1-C6烷基或C2-C6烯基基团；或者R3、R4和R5如上所定义，而R6和R7连同它们所连接的碳原子形成C5-C6环烷基或环烯基基团。
• 10.1016/j.molstruc.2024.138950
  作者：Sindi, Kais、Elleuch, Haitham、Ayari, Sami、Mansour, Lamjed、Sauthier, Mathieu、hamdi, Naceur

  DOI：10.1016/j.molstruc.2024.138950

  日期：——

  Carbonyl reductions using NaBH are generally high-yielding and highly selective processes commonly used in organic synthesis and the pharmaceutical industry. However, the reaction is exothermic, and the stability of the NaBH solution is limited, resulting in long reaction times. In this work, efficient reductions of MBH alcohols with CeCl/NaBH in MeOH are reported . Furthemore in this method, aluminum

  使用 NaBH 进行羰基还原通常是有机合成和制药工业中常用的高产率和高选择性过程。然而，该反应是放热的，并且NaBH溶液的稳定性有限，导致反应时间较长。在这项工作中，报道了在 MeOH 中用 CeCl/NaBH 有效还原 MBH 醇。此外，在该方法中，使用异丙醇铝和异丁醇作为转移过程中的质子源。该方法表现出令人印象深刻的选择性和高产率，从而形成所需的双齿烯丙醇。
• TAKAKI, KEN;YASUMURA, MASATERU;NEGORO, KENJI, J. ORG. CHEM., 1983, 48, N 1, 54-57
  作者：TAKAKI, KEN、YASUMURA, MASATERU、NEGORO, KENJI

  DOI：——

  日期：——