6-chloroindolyl-3-α-oxoacetamide | 98993-96-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 6-chloroindolyl-3-α-oxoacetamide
• 英文别名: 6-Chlor-indolyl-3-glyoxalamid；2-(6-chloro-indol-3-yl)-2-oxo-acetamide；2-(6-chloro-1H-indol-3-yl)-2-oxoacetamide
• CAS: 98993-96-5
• 化学式: C₁₀H₇ClN₂O₂
• 分子量: 222.631
• InChiKey: MKCWCJGRPAXGMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-chloroindolyl-3-α-oxoacetamide 在 氯化亚砜 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以95%的产率得到6-chloroindolyl-3-carbonylnitrile
  参考文献：
  名称：

  A new synthesis of versatile indolyl-3-carbonylnitriles

  摘要：

  Indolyl-3-carbonylnitriles are compounds with demonstrated utility as intermediates in organic chemistry. However, their synthesis remains a challenge, requiring the use of toxic sources Of cyanide, and often proceeding in low yields. Accordingly, presented here is a new synthesis of these versatile reactants, via dehydration of easily accessible alpha-oxoacetamides in generally high yields under simple reaction conditions. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.07.075
• 作为产物：
  描述：

  2-(6-chloro-1H-indol-3-yl)-2-oxoacetyl chloride 在 氯化铵 、 potassium hydroxide 作用下， 以 水 为溶剂， 生成 6-chloroindolyl-3-α-oxoacetamide
  参考文献：
  名称：

  A new synthesis of versatile indolyl-3-carbonylnitriles

  摘要：

  Indolyl-3-carbonylnitriles are compounds with demonstrated utility as intermediates in organic chemistry. However, their synthesis remains a challenge, requiring the use of toxic sources Of cyanide, and often proceeding in low yields. Accordingly, presented here is a new synthesis of these versatile reactants, via dehydration of easily accessible alpha-oxoacetamides in generally high yields under simple reaction conditions. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.07.075

文献信息

• [EN] INDOLE DERIVATIVES FOR THE STIMULATION OF STEM CELL PROLIFERATION<br/>[FR] DÉRIVÉS INDOLE DESTINÉS À STIMULER LA PROLIFÉRATION DE CELLULES SOUCHES
  申请人：UNIV SHEFFIELD

  公开号：WO2010139982A1

  公开（公告）日：2010-12-09

  The present invention relates to indole derivatives of formula (I) and Formula (II) which possess potent antiprion activity and stem cell proliferative properties. The invention also relates to the use of such compounds to treat prion-related diseases and in stem cell therapies.
• A new synthesis of versatile indolyl-3-carbonylnitriles
  作者：Clinton G.L. Veale

  DOI：10.1016/j.tetlet.2015.07.075

  日期：2015.9

  Indolyl-3-carbonylnitriles are compounds with demonstrated utility as intermediates in organic chemistry. However, their synthesis remains a challenge, requiring the use of toxic sources Of cyanide, and often proceeding in low yields. Accordingly, presented here is a new synthesis of these versatile reactants, via dehydration of easily accessible alpha-oxoacetamides in generally high yields under simple reaction conditions. (C) 2015 Elsevier Ltd. All rights reserved.