6^A-O-phosphono-β-cyclodextrin | 62802-59-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6^A-O-phosphono-β-cyclodextrin
• 英文别名: [(1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31S,33R,35R,36R,37R,38R,39R,40R,41R,42R,43R,44R,45R,46R,47R,48R,49R)-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecahydroxy-5,15,20,25,30,35-hexakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontan-10-yl]methyl dihydrogen phosphate
• CAS: 62802-59-9
• 化学式: C₄₂H₇₁O₃₈P
• 分子量: 1214.98
• InChiKey: FJJPKKXFEOZCOF-FOUAGVGXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -16.1
• 重原子数：
  81
• 可旋转键数：
  9
• 环数：
  21.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  601
• 氢给体数：
  22
• 氢受体数：
  38

反应信息

• 作为产物：
  描述：

  6^A-O-(diphenoxyphosphoryl)-β-cyclodextrin 在 platinum(IV) oxide 水 、 氢气 作用下， 以 甲醇 为溶剂， 反应 72.0h， 以146 mg的产率得到6^A-O-phosphono-β-cyclodextrin
  参考文献：
  名称：

  Effective synthesis of negatively charged cyclodextrins. Selective access to phosphate cyclodextrins

  摘要：

  We report the selective preparation of alpha- and beta-cyclodextrins bearing one and two phosphate moieties on the primary rim. These compounds were prepared by selective O-debenzylation of fully protected derivatives, followed by phosphorylation and deprotection. The synthesis of an a-cyclodextrin with both, a carboxylic group and a phosphate moiety on primary positions is also described. Title compounds are examples of negatively charged cyclodextrins that might be of interest in studying the complexation of cationic guests. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.05.094

文献信息

• ORGANIC-INORGANIC HYBRID SOLID HAVING A MODIFIED OUTER SURFACE
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS

  公开号：US20150150981A1

  公开（公告）日：2015-06-04

  The present invention concerns metal-organic hybrid solids having a modified outer surface. These solids can be used, for example, for the storage and vectoring of molecules of interest such as pharmaceutically active ingredients, compounds of interest in cosmetics and markers, for example contrast agents. These solids have good results in terms of active drug loading capacities, biocompatibility, stability and controlling the release of the active ingredients encapsulated.

  本发明涉及具有改性外表面的金属-有机混合固体。这些固体可以用于存储和载体化感兴趣的分子，例如药用活性成分、化妆品中感兴趣的化合物和标记物，例如对比剂。这些固体在活性药物装载能力、生物相容性、稳定性和控制封装的活性成分释放方面取得了良好的结果。
• Pharmaceutical compositions comprising aminoadamantane derivatives
  申请人：Merz Pharma GmbH & Co. KGaA

  公开号：EP2138173A1

  公开（公告）日：2009-12-30

  The present invention relates to pharmaceutical compositions comprising 1-aminoadamantane derivatives and a cyclodextrin, which compositions exhibit advantageous safety, convenience, and dosing characteristics. The compositions of the instant invention find particular application in the treatment of various diseases and conditions of the CNS, including those involving the impairment of cognitive function or dementia, such as Alzheimer's disease.

  本发明涉及含有1-氨基金刚烷衍生物和环糊精的药物组合物，该组合物表现出有利的安全性、便利性和给药特性。本发明的组合物在治疗各种中枢神经系统疾病和病情方面具有特殊应用，包括涉及认知功能或痴呆症的损害，如阿尔茨海默病。
• Optically fluorescent nanoparticles
  申请人：Schering AG

  公开号：EP1760467A1

  公开（公告）日：2007-03-07

  The present invention refers to nanoparticles having optically fluorescent activity. In more detail, the invention refers to a nanoparticle matrix comprising a co-aggregate of at least one charged polyelectrolyte and at least one oppositely charged active agent, wherein the active agent is a hydrophilic optically fluorescent agent, and the invention further refers to a nanoparticle comprising said nanoparticle matrix. Optionally, the nanoparticle is surface modified. The invention also refers to a method for preparing said nanoparticle, and to a method of surface modification. Furthermore, the invention refers to uses of said nanoparticle in vitro and in vivo, and to methods for in vitro and in vivo diagnosis.

  本发明涉及具有光学荧光活性的纳米颗粒。更具体地说，本发明涉及一种纳米颗粒基质，其包括至少一种带电聚电解质和至少一种相反带电的活性剂的共聚物，其中活性剂是亲水性光学荧光剂，本发明还涉及包括该纳米颗粒基质的纳米颗粒。可选地，纳米颗粒可以表面修饰。本发明还涉及制备该纳米颗粒的方法和表面修饰的方法。此外，本发明还涉及在体外和体内使用该纳米颗粒的用途，以及体外和体内诊断的方法。
• Organic-inorganic hybrid solid having a modified outer surface
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS

  公开号：US10159738B2

  公开（公告）日：2018-12-25

  The present invention concerns metal-organic hybrid solids having a modified outer surface. These solids can be used, for example, for the storage and vectoring of molecules of interest such as pharmaceutically active ingredients, compounds of interest in cosmetics and markers, for example contrast agents. These solids have good results in terms of active drug loading capacities, biocompatibility, stability and controlling the release of the active ingredients encapsulated.

  本发明涉及具有改性外表面的金属有机杂化固体。例如，这些固体可用于储存和载体化相关分子，如药物活性成分、化妆品中的相关化合物和标记物，如造影剂。这些固体在活性药物负载能力、生物相容性、稳定性和控制所封装活性成分的释放方面都有很好的效果。
• Therapeutic patch useful for the treatment of hemorrhoids
  申请人：——

  公开号：US20020192273A1

  公开（公告）日：2002-12-19

  The present invention provides an adhesive patch that includes a flexible backing having a front side and a back side. A therapeutic formulation is positioned on at least a portion of the front side of the backing, in at least a portion of the front side of the backing, or on and in at least a portion of the front side of the backing. The therapeutic formulation includes a vasoconstrictor, a solvent that dissolves the vasoconstrictor, and a pressure sensitive adhesive. The present invention also provides methods of medical use that employ the patch of the present invention. Such uses include, e.g., treating or preventing hemorrhoids in a mammal, providing relief from the discomfort associated with hemorrhoids, providing post-operative relief from discomfort associated with the surgical treatment of hemorrhoids, treating or preventing a bacterial infection associated with hemorrhoids, preventing a bacterial infection associated with the surgical treatment of hemorrhoids, absorbing exudate, blood, or a combination thereof from the region of the anus of a mammal inflicted with hemorrhoids, and absorbing exudate, blood, or a combination thereof from the region of the anus of a mammal during the post-operative treatment of hemorrhoids.

  本发明提供了一种粘性贴片，它包括具有正面和背面的柔性背衬。治疗配方至少位于背衬正面的一部分、背衬正面的至少一部分或背衬正面的至少一部分。治疗配方包括血管收缩剂、溶解血管收缩剂的溶剂和压敏粘合剂。本发明还提供了采用本发明贴片的医疗使用方法。这些用途包括治疗或预防哺乳动物的痔疮，缓解与痔疮相关的不适，缓解与痔疮手术治疗相关的术后不适，治疗或预防与痔疮相关的细菌感染、防止与痔疮手术治疗相关的细菌感染，吸收患痔疮的哺乳动物肛门区域的渗出物、血液或其组合，以及在痔疮术后治疗期间吸收哺乳动物肛门区域的渗出物、血液或其组合。