4-hydroxy-2-oxo-4-phenylbut-3-enoic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 4-hydroxy-2-oxo-4-phenylbut-3-enoic acid
• 化学式: C₁₀H₈O₄
• 分子量: 192.17
• InChiKey: QXZSEJLYYQDPRN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Method and materials for the microbiological oxidation of aromatic hydrocarbons
  申请人：AMGEN INC.

  公开号：EP0103887A2

  公开（公告）日：1984-03-28

  Disclosed are novel DNA sequences susceptible to expression in a microorganism in the form of synthesis of one or more enzymes participative in the microbiological oxidative degradation of a selected aromatic hydrocarbon substrate to a selected oxidized compound which is an intermediate in a multiple enzyme-catalyzed degradative pathway for total mineralization of said substrate. The DNA sequences are characterized by being substantially free from operative association with DNA sequences susceptible to expression in the form of synthesis of one or more enzymes participative in oxidative degradation of said selected intermediate compound. Illustrative of the invention is a plasmidborne DNA sequence of Pseudomonas putida origin which codes for expression, in a host microorganism such as E coli, of enzymes participative in the oxidative degradation of naphthalene to salicylate. Cultured growth of stably transformed host cells in a medium including a naphthalene substrate results in quantitative naphthalene degradation and accumulation of isolatable quantities of, e.g., salicylate products.

  本发明公开了可在微生物中以合成一种或多种酶的形式表达的新型DNA序列，这些酶可参与选定芳香烃底物的微生物氧化降解，将其转化为选定的氧化化合物，该氧化化合物是所述底物完全矿化的多种酶催化降解途径中的中间产物。DNA 序列的特征是基本上不与 DNA 序列发生作用关联，这些 DNA 序列容易以合成一种或多种参与所述选定中间化合物氧化降解的酶的形式表达。本发明的例证是一种源自假单胞菌（Pseudomonas putida）的质粒DNA序列，其编码可在宿主微生物（如大肠杆菌）中表达参与将萘氧化降解为水杨酸的酶。稳定转化的宿主细胞在含有萘底物的培养基中培养生长，可定量降解萘，并积累可分离的水杨酸产物等。
• Fermentation route for the production of levulinic acid, levulinate esters and valerolactone and derivatives thereof
  申请人：Arzeda Corp.

  公开号：US10246727B2

  公开（公告）日：2019-04-02

  The invention provides processes for the conversion of pyruvate obtained from sugars or other carbon sources, to valuable C5 materials such as levulinic acid, levulinate esters, valerolactone, and derivatives thereof.

  本发明提供了将从糖或其他碳源中获得的丙酮酸转化为有价值的 C5 材料（如乙酰丙酮酸、乙酰丙酮酸酯、戊内酯及其衍生物）的工艺。
• DNA SHUFFLING OF MONOOXYGENASE GENES FOR PRODUCTION OF INDUSTRIAL CHEMICALS
  申请人：Maxygen, Inc.

  公开号：EP1104459A1

  公开（公告）日：2001-06-06
• FERMENTATION ROUTE FOR THE PRODUCTION OF LEVULINIC ACID, LEVULINATE ESTERS AND VALEROLACTONE AND DERIVATIVES THEREOF
  申请人：Zanghellini Alexandre Luc

  公开号：US20130330779A1

  公开（公告）日：2013-12-12

  The invention provides processes for the conversion of pyruvate obtained from sugars or other carbon sources, to valuable C5 materials such as levulinic acid, levulinate esters, valerolactone, and derivatives thereof.
• US9523105B2
  申请人：——

  公开号：US9523105B2

  公开（公告）日：2016-12-20