2-(3-(4-Chlorophenyl)-1-(3-methoxyphenyl)-3-oxopropyl)malononitrile

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: 2-(3-(4-Chlorophenyl)-1-(3-methoxyphenyl)-3-oxopropyl)malononitrile
• 英文别名: 2-[3-(4-chlorophenyl)-1-(3-methoxyphenyl)-3-oxopropyl]propanedinitrile
• 化学式: C₁₉H₁₅ClN₂O₂
• 分子量: 338.8
• InChiKey: ZJOCKWJYQSJGHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  73.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Anti-infective compounds
  申请人：Brodin Priscille

  公开号：US20110178077A1

  公开（公告）日：2011-07-21

  The present invention relates to small molecule compounds and their use in the treatment of bacterial infections, in particular Tuberculosis.

  本发明涉及小分子化合物及其在治疗细菌感染，特别是结核病方面的用途。
• INHIBITORS OF FILOVIRUS ENTRY INTO HOST CELLS
  申请人：Basu Arnab

  公开号：US20120189614A1

  公开（公告）日：2012-07-26

  Organic compounds showing the ability to inhibit viral glycoprotein (GP)-mediated entry of a filovirus into a host cell are disclosed. The disclosed filovirus entry inhibitor compounds are useful for treating, preventing, or reducing the spread of infections by filovirus including the type species Marburg virus (MARV) and Ebola virus (EBOV). Preferred inhibitors of the invention provide therapeutic agents for combating the Ivory Coast, Sudan, Zaire, Bundibugyo, and Reston Ebola virus strains.

  本发明揭示了有机化合物，表现出抑制病毒糖蛋白（GP）介导的菲罗病毒进入宿主细胞的能力。所揭示的菲罗病毒进入抑制剂化合物可用于治疗、预防或减少菲罗病毒感染的传播，包括类型种马尔堡病毒（MARV）和埃博拉病毒（EBOV）。本发明的优选抑制剂为治疗象牙海岸、苏丹、扎伊尔、邦迪布吉奥和雷斯顿埃博拉病毒株提供治疗剂。
• US8785452B2
  申请人：——

  公开号：US8785452B2

  公开（公告）日：2014-07-22
• US9101635B2
  申请人：——

  公开号：US9101635B2

  公开（公告）日：2015-08-11
• [EN] INHIBITORS OF FILOVIRUS ENTRY INTO HOST CELLS<br/>[FR] INHIBITEURS D'ENTRÉE DE FILOVIRUS DANS DES CELLULES HÔTES
  申请人：MICROBIOTIX INC

  公开号：WO2011046646A2

  公开（公告）日：2011-04-21

  Organic compounds showing the ability to inhibit viral glycoprotein (GP)-mediated entry of a filovirus into a host cell are disclosed. The disclosed filovirus entry inhibitor compounds are useful for treating, preventing, or reducing the spread of infections by filovirus including the type species Marburg virus (MARV) and Ebola virus (EBOV). Preferred inhibitors of the invention provide therapeutic agents for combating the Ivory Coast, Sudan, Zaire, Bundibugyo, and Reston Ebola virus strains.