4-[[5-(4-Methylphenyl)-1,3-oxazol-2-yl]amino]phenol | 1222343-85-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-[[5-(4-Methylphenyl)-1,3-oxazol-2-yl]amino]phenol
• CAS: 1222343-85-2
• 化学式: C₁₆H₁₄N₂O₂
• 分子量: 266.299
• InChiKey: WXGBSPWAEMBLEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  58.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-叠氮基-1-(4-甲基苯基)乙酮 、 4-异硫氰酸基-苯酚 在 resin-bound triphenylphosphine 作用下， 以 1,4-二氧六环 为溶剂， 生成 4-[[5-(4-Methylphenyl)-1,3-oxazol-2-yl]amino]phenol
  参考文献：
  名称：

  2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97)

  摘要：

  Valosin-containing protein (VCP; also known as p97) is a member of the AAA ATPase family with a central role in the ubiquitin-degradation of misfolded proteins. VCP also exhibits antiapoptotic function and metastasis via activation of nuclear factor kappa-B signaling pathway. We have discovered that 2-anilino-4-aryl-1,3-thiazoles are potent drug-like inhibitors of this enzyme. The identified compounds show low nanomolar VCP potency, demonstrate SAR trends, and show activity in a mechanism based cellular assay. This series of compounds represents the first steps towards a novel, small molecule VCP inhibitor as a cancer therapeutic. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.01.058