1,1’-(1,4-phenylene)bis(3-(3-chlorophenyl)prop-2-en-1-one) | 1326770-77-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1,1’-(1,4-phenylene)bis(3-(3-chlorophenyl)prop-2-en-1-one)
• 英文别名: (E)-3-(3-chlorophenyl)-1-[4-[(E)-3-(3-chlorophenyl)prop-2-enoyl]phenyl]prop-2-en-1-one
• CAS: 1326770-77-7
• 化学式: C₂₄H₁₆Cl₂O₂
• 分子量: 407.296
• InChiKey: ZPDVGIKWRQBHAA-FNCQTZNRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,4-二乙酰苯 、 3-氯苯甲醛 在 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 0.2h， 以88%的产率得到1,1’-(1,4-phenylene)bis(3-(3-chlorophenyl)prop-2-en-1-one)
  参考文献：
  名称：

  Synthesis, characterization and antimicrobial activities of some novel bis-chalcones

  摘要：

  A series of novel bis-chalcones 3a-n were synthesized in excellent yields by condensation reaction of 1,4-diacetylbenzene with various aldehydes in ethanol 96% and aqueous NaOH at room temperature. All compounds were characterized by IR, H-1 and C-13 NMR, UV spectroscopy and elemental analysis. The antimicrobial activities of synthesized compounds were also evaluated. The most of these compounds exhibited a good activity against Staphylococcus aureus, Escherichia coli and Candida albicans microorganisms. Some of them showed significant activities.

  DOI：

  10.1007/s00044-011-9696-z

文献信息

• Synthesis, characterization and antimicrobial activities of some novel bis-chalcones
  作者：Akbar Mobinikhaledi、Mehdi Kalhor、Hossein Jamalifar

  DOI：10.1007/s00044-011-9696-z

  日期：2012.8

  A series of novel bis-chalcones 3a-n were synthesized in excellent yields by condensation reaction of 1,4-diacetylbenzene with various aldehydes in ethanol 96% and aqueous NaOH at room temperature. All compounds were characterized by IR, H-1 and C-13 NMR, UV spectroscopy and elemental analysis. The antimicrobial activities of synthesized compounds were also evaluated. The most of these compounds exhibited a good activity against Staphylococcus aureus, Escherichia coli and Candida albicans microorganisms. Some of them showed significant activities.