4-isopropyl-2-methylenebutyrolactone | 29044-01-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 4-isopropyl-2-methylenebutyrolactone
• 英文别名: 3-Methylidene-5-propan-2-yloxolan-2-one
• CAS: 29044-01-7
• 化学式: C₈H₁₂O₂
• 分子量: 140.182
• InChiKey: YKAUVLADLMSRDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-hydroxy-N-(2-methoxyphenyl)-5-methyl-2-methylenehexanamide 在 盐酸 作用下， 反应 3.0h， 以78%的产率得到4-isopropyl-2-methylenebutyrolactone
  参考文献：
  名称：

  Asymmetric synthesis of .alpha.-methylene-.gamma.-butyrolactones using chiral N-monosubstituted 2-[(tributylstannyl)methyl]propenamides

  摘要：

  DOI：

  10.1021/jo00360a038

文献信息

• Direct indium-promoted preparation of α-methylene-γ-lactones from 2-(bromomethyl)acrylic acid and carbonyl compounds
  作者：Prabir K Choudhury、Francisco Foubelo、Miguel Yus

  DOI：10.1016/s0040-4020(99)00593-1

  日期：1999.8

  The reaction of 2-(bromomethyl)acrylic acid (2) with different carbonyl compounds 1 [CH2O, , c-C6H11CHO, Ph2CHCHO, (CH2)5CO, furfural, 1,4-cyclohexanedione, 2-chlorocyclohexanone, 2-hydroxybenzaldehyde, phthaldehyde, N-Boc-3-indolecarboxaldehyde, cholestanone, (1R)-(−)-myrtenal] and indium powder in a 1:1 THF:H2O mixture at room temperature affords, after acidic work-up with 6M hydrochloric acid, the

  2-（溴甲基）丙烯酸（2）与不同的羰基化合物1 [CH 2 O ，，c -C 6 H 11 CHO，Ph 2 CHCHO，（CH 2）5 CO，糠醛，1,4-环己二酮的反应室温下，在1：1 THF：H 2 O混合物中，苯甲酸，2-氯环己酮，2-羟基苯甲醛，邻苯二甲醛，N -Boc-3-吲哚甲醛，胆甾烷酮，（1 R）-（-）-myrtenal]和铟粉得到，用6M盐酸进行酸性处理后，得到相应的α-亚甲基-γ-内酯3。
• Indium-promoted preparation of substituted α-methylene-γ-lactones from 2-(bromomethyl)acrylic acid and carbonyl compounds
  作者：Prabir K. Choudhury、Francisco Foubelo、Miguel Yus

  DOI：10.1016/s0040-4039(98)00554-1

  日期：1998.5

  The reaction of 2-(bromomethyl)acrylic acid (1) with different carbonyl compounds (2) [CH2O, (E)-CH3CH=CHCHO, PriCHO, ButCHO, PhCHO, CH3(CH2)5CHO, c-C6H11CHO, Ph2CHCHO, (CH2)5CO] and indium powder in a 1:1 THF:H2O mixture at room temperatme affords, after acidic work-up with hydrochloric acid, the corresponding α-methylene-γ-butyrolactones 3.

  的2-（溴甲基）丙烯酸（反应1）具有不同的羰基化合物（2）[CH 2 O，（ë）-CH 3 CH = CHCHO，镨我CHO，卜吨CHO，苯甲醛，CH 3（CH 2）在室温下用酸性酸处理后，在1：1 THF：H 2 O混合物中的5 CHO，c -C 6 H 11 CHO，Ph 2 CHCHO，（CH 2）5 CO]和铟粉，相应的α-亚甲基-γ-丁内酯3。
• Electrogenerated zinc as the catalyst in the allylation of carbonyl compounds direct synthesis of α-methylene-γ-lactones
  作者：Y. Rollin、S. Derien、E. Duñach、C. Gebehenne、J. Perichon

  DOI：10.1016/s0040-4020(01)87246-x

  日期：1993.8

  The electroreduction of a catalytic amount of ZnBr2 in acetonitrile provided a active Zn*, able to catalyze the reductive coupling of allyl bromides and chlorides with carbonyl compounds with high regioselectivity. Substituted α-methylene γ-lactones were obtained from functionalized allyl derivatives.

  乙腈中催化量的ZnBr 2的电还原可提供活性Zn *，该催化剂能够以高区域选择性催化烯丙基溴和氯化物与羰基化合物的还原偶联。从官能化的烯丙基衍生物获得取代的α-亚甲基γ-内酯。
• POLYMERIZABLE LIQUID CRYSTAL COMPOUND, COMPOSITION, LIQUID CRYSTAL POLYMERIZATION FILM-KIND THEREOF AND USE THEREOF
  申请人：JNC CORPORATION

  公开号：US20170174992A1

  公开（公告）日：2017-06-22

  An object is to provide a polymerizable liquid crystal compound, a polymerizable liquid crystal composition containing the compound and liquid crystal polymerization film-kind capable of controlling chromatic dispersion characteristics and having low positive chromatic dispersion characteristics. An aspect can be exemplified in which the polymerizable liquid crystal compound is represented by formula (1): in which, in formula (1), G is a group composed of a quinoline skeleton, an isoquinoline skeleton, a quinoxaline skeleton or a quinazoline skeleton, A 1 is 1,4-phenylene or 1,4-cyclohexylene, Z 1 is a connecting group, m is an integer from 0 to 3, and R 1 is a group containing a polymerizable group.

  提供一种可聚合的液晶化合物，包含该化合物的可聚合液晶组合物以及能够控制色散特性并具有低正色散特性的液晶聚合膜。一种例子是该可聚合液晶化合物由式(1)表示：其中，在式(1)中，G是由喹啉骨架、异喹啉骨架、喹啉骨架或喹嗪骨架组成的基团，A1为1,4-苯基或1,4-环己基，Z1为连接基，m为0至3的整数，R1为含有可聚合基团的基团。
• POLYMERIZABLE LIQUID CRYSTAL COMPOUND, POLYMERIZABLE LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL POLYMERIZED FILMS
  申请人：JNC CORPORATION

  公开号：US20180119014A1

  公开（公告）日：2018-05-03

  To provide a polymerizable liquid crystal compound in order to produce a retardation film having excellent front contrast. A polymerizable liquid crystal composition including a compound represented by Formula (1). In Formula (1), for example, W 1 is an alkoxycarbonyl group having 1 to 10 carbon atoms, an alkanoyl group having 1 to 10 carbon atoms, or a polymerizable functional group, A 1 is independently 1,4-phenylene or naphthalene-2,6-diyl, Z 1 is a linking group, m and n are independently an integer of 0 to 7, and satisfy 3≤m+n≤8, and P 1 is a polymerizable functional group.

  为了生产具有优异前对比度的减速膜，提供一种可聚合液晶化合物。包括由式（1）表示的化合物的可聚合液晶组合物。在式（1）中，例如，W1是具有1至10个碳原子的烷氧羰基、具有1至10个碳原子的烷酰基或可聚合官能团，A1独立地为1,4-苯撑或萘-2,6-二基，Z1为连接基，m和n独立地为0至7的整数，并满足3≤m+n≤8，P1为可聚合官能团。