B-[6-(3-吡啶氧基)-3-吡啶]-硼酸 | 918138-38-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: B-[6-(3-吡啶氧基)-3-吡啶]-硼酸
• 英文名称: 6-(pyridin-3-yloxy)pyridin-3-yl boronic acid
• 英文别名: 6-(Pyridin-3-yloxy)pyridine-3-boronic acid；(6-pyridin-3-yloxypyridin-3-yl)boronic acid
• CAS: 918138-38-2
• 化学式: C₁₀H₉BN₂O₃
• 分子量: 216.004
• InChiKey: OKBZLPTXOVQGGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.05
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  75.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  B-[6-(3-吡啶氧基)-3-吡啶]-硼酸 、 邻溴苯甲醛 在 四(三苯基膦)钯 sodium carbonate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 15.0h， 以31%的产率得到2-[6-(pyridin-3-yloxy)pyridin-3-yl]benzaldehyde
  参考文献：
  名称：

  Novel oxybispyridylboronic acids: synthesis and study of their reactivity in Suzuki-type cross-coupling reactions

  摘要：

  This paper sets forth the synthesis of novel oxybispyridylboronic acids, which are prepared from the corresponding halo-oxybispyridines via halogen-metal exchange using n-butyllithium and treatment with triisopropylborate. A range of efficient cross-coupling reactions of these novel boronic acids with selected aryl halides is described. This strategy produces novel pyridylethers of interest in cholinergic medicinal chemistry. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.09.036
• 作为产物：
  描述：

  3-bromo-6-(pyridin-3-yloxy)pyridine 在 正丁基锂 、 硼酸三异丙酯 作用下， 以 乙醚 为溶剂， 反应 1.5h， 以8%的产率得到B-[6-(3-吡啶氧基)-3-吡啶]-硼酸
  参考文献：
  名称：

  Novel oxybispyridylboronic acids: synthesis and study of their reactivity in Suzuki-type cross-coupling reactions

  摘要：

  This paper sets forth the synthesis of novel oxybispyridylboronic acids, which are prepared from the corresponding halo-oxybispyridines via halogen-metal exchange using n-butyllithium and treatment with triisopropylborate. A range of efficient cross-coupling reactions of these novel boronic acids with selected aryl halides is described. This strategy produces novel pyridylethers of interest in cholinergic medicinal chemistry. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.09.036

文献信息

• SUBSTITUTED PHENYLALANINE DERIVATIVES
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20160280699A1

  公开（公告）日：2016-09-29

  The invention relates to substituted phenylalanine derivatives and to processes for preparation thereof, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders and/or severe perioperative blood loss.

  该发明涉及取代苯丙氨酸衍生物及其制备方法，以及其用于生产治疗和/或预防疾病的药物，特别是心血管疾病和/或严重围手术期失血的药物。
• Novel oxybispyridylboronic acids: synthesis and study of their reactivity in Suzuki-type cross-coupling reactions
  作者：Anne Sophie Voisin、Alexandre Bouillon、Inmaculada Berenguer、Jean-Charles Lancelot、Aurélien Lesnard、Sylvain Rault

  DOI：10.1016/j.tet.2006.09.036

  日期：2006.12

  This paper sets forth the synthesis of novel oxybispyridylboronic acids, which are prepared from the corresponding halo-oxybispyridines via halogen-metal exchange using n-butyllithium and treatment with triisopropylborate. A range of efficient cross-coupling reactions of these novel boronic acids with selected aryl halides is described. This strategy produces novel pyridylethers of interest in cholinergic medicinal chemistry. (c) 2006 Elsevier Ltd. All rights reserved.