1-(4-chlorophenyl)-1,2-dihydrobenzo[f]quinolin-3(4H)-one | 64257-45-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(4-chlorophenyl)-1,2-dihydrobenzo[f]quinolin-3(4H)-one
• 英文别名: 1-(4-Chlorophenyl)-1H,2H,3H,4H-benzo[F]quinolin-3-one；1-(4-chlorophenyl)-2,4-dihydro-1H-benzo[f]quinolin-3-one
• CAS: 64257-45-0
• 化学式: C₁₉H₁₄ClNO
• 分子量: 307.779
• InChiKey: AQJRALPRSIVPKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(4-chlorophenyl)-1,2-dihydrobenzo[f]quinolin-3(4H)-one 以90%的产率得到
  参考文献：
  名称：

  STRODS YA. A.; KAMPARE R. B.; LIELBRIEDIS N. EH.; NEJLAND O. YA., IZV. AN LATVSSR. CEP. XIM., 1977, HO

  摘要：

  DOI：
• 作为产物：
  描述：

  丙二酸环(亚)异丙酯 、 N-[(E)-(4-chlorophenyl)methylidene]naphthalen-2-amine 以67%的产率得到
  参考文献：
  名称：

  STRODS YA. A.; KAMPARE R. B.; LIELBRIEDIS I. EH.; NEJLAND O. YA., XIMIYA GETEROTSIKL. SOEDIN., 1977, HO 7, 973-976

  摘要：

  DOI：

文献信息

• A simple and clean procedure for the synthesis of polyhydroacridine and quinoline derivatives: reaction of Schiff base with 1,3-dicarbonyl compounds in aqueous medium
  作者：Xiang-Shan Wang、Mei-Mei Zhang、Zhao-Sen Zeng、Da-Qing Shi、Shu-Jiang Tu、Xian-Yong Wei、Zhi-Min Zong

  DOI：10.1016/j.tetlet.2005.08.091

  日期：2005.10

  A clean and simple synthesis of benzo[c]acridine, benzo[a]acridine, pyrido[2,3-c]acridine and benzo[f]quinoline derivatives was accomplished in good to excellent yields via the reaction of Schiff base with 1,3-dicarbonyl compounds in aqueous medium catalyzed by TEBA. The structures were characterized by 1H NMR, IR and elemental analysis, and confirmed by X-ray diffraction study.

  通过席夫碱与1的反应，可以很好地收率很好地完成苯并[ c ] ac啶，苯并[ a ] ac啶，吡啶并[2,3- c ] ac啶和苯并[ f ]喹啉衍生物的清洁，简单合成。TEBA催化的水性介质中的3-二羰基化合物。通过1 H NMR，IR和元素分析对结构进行表征，并通过X射线衍射研究证实。
• Three Component One-Pot Synthesis of 1-Aryl-4-benzo[f]quinoline Derivatives in Glycerol
  作者：Xue-Mei Wang、Xin Ma、Hai-Long Ma

  DOI：10.14233/ajchem.2015.18100

  日期：——

  A series of 1-aryl-1,2-dihydrobenzo[f]quinolin-3(4H)one derivatives were synthesized by one-pot muticomponent reaction of Meldrums acid with benzaldehyde, naphthalene-2-amine in glycerol. Glycerol, a new green organic solvent, it not only acts as a catalyst but also as a recyclable solvent by significantly enhancing the intramolecular cyclization. When compared with classical methods, this method has the advantages of milder reaction conditions, good yields, easy processing and environmental benignity. All compounds were characterized by elemental analysis, FT-IR and 1H NMR spectra.

  在甘油中，通过梅氏酸与苯甲醛、萘-2-胺的单锅突变组分反应，合成了一系列 1-芳基-1,2-二氢苯并[f]喹啉-3(4H)-1 衍生物。甘油是一种新型的绿色有机溶剂，它不仅可以作为催化剂，还可以作为可回收溶剂，显著提高分子内环化作用。与传统方法相比，该方法具有反应条件温和、产率高、易于加工和环保等优点。所有化合物都通过元素分析、傅立叶变换红外光谱和 1H NMR 光谱进行了表征。
• One-pot synthesis of benzoquinoline and coumarin derivatives using Meldrum’s acid in three-component reactions
  作者：Xue-Mei Wang、He-Lin Ye、Zheng-Jun Qaun、Xi-Cun Wang

  DOI：10.1007/s11164-012-0762-z

  日期：2013.7

  A series of 1-aryl-1,2-dihydrobenzo[f]quinolin-3(4H)-one derivatives and 4-aryl-7,7-dimethyl-5-oxo-3,4,5,6,7,8-hexahydrocoumarin derivatives have been synthesized by one-pot multicomponent reaction of Meldrum’s acid with benzaldehyde, naphthalene-2-amine, or cyclohexanedione in PEG-400. The method has the advantages of mild reaction conditions, good yields, and easy processing, and is environmentally

  一系列1-芳基-1,2-二氢苯并[ f ]喹啉-3（4 H）-一衍生物和4-芳基-7,7-二甲基-5-氧代-3,4,5,6,7，通过Meldrum的酸与苯甲醛，萘-2-胺或环己二酮在PEG-400中的一锅多组分反应合成了8-六氢香豆素衍生物。该方法的优点是反应条件温和，收率好，易加工，对环境无害。
• Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity
  申请人：Lindquist Susan L.

  公开号：US20080261953A1

  公开（公告）日：2008-10-23

  Compounds and compositions are provided for treatment or amelioration of one or more symptoms of α-synuclein toxicity, α-synuclein mediated diseases or diseases in which α-synuclein fibrils are a symptom or cause of the disease. In one embodiment, the compounds for use in the compositions and methods are heteroaryl acylguanidines, heteroarylhydrazones, dihy-dropyridones, heteroaryl and aryl styryl ketones, and heteroarylpyrazoles.

  提供了化合物和组合物，用于治疗或缓解α-突触核蛋白毒性、α-突触核蛋白介导的疾病或α-突触核蛋白纤维是疾病症状或病因的疾病中的一个或多个症状。在一种实施例中，用于组合物和方法的化合物是杂环基酰基胍、杂环基腙、二氢吡啶酮、杂环基和芳基苯乙酮以及杂环基吡唑。
• Compounds, compositions and methods of inhibiting a-synuclein toxicity
  申请人：The Whitehead Institute for Biomedical Research

  公开号：EP2433634A2

  公开（公告）日：2012-03-28

  Compounds and compositions are provided for treatment or amelioration of one or more symptoms of a-synuclein toxicity, a-synuclein mediated diseases or diseases in which a-synuclein fibrils are a symptom or cause of the disease. In one embodiment, the compounds for use in the compositions and methods are heteroaryl acylguanidines, heteroarylhydrazones, dihydropyridones, heteroaryl and aryl styryl ketones, and heteroarylpyrazoles.

  提供的化合物和组合物用于治疗或改善a-突触核蛋白毒性、a-突触核蛋白介导的疾病或a-突触核蛋白纤维是症状或病因的疾病的一种或多种症状。在一个实施方案中，用于组合物和方法的化合物是杂芳基酰基胍、杂芳基肼、二氢吡啶酮、杂芳基和芳基苯乙烯基酮以及杂芳基吡唑。