4-[3,4-(methylendioxy)phenoxy]phthalonitrile | 850554-73-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-[3,4-(methylendioxy)phenoxy]phthalonitrile
• 英文别名: 4-[3,4-(methylenedioxy)phenoxy]phthalonitrile；4-(benzo[1,3]dioxol-5-yloxy)-phthalonitrile；4-(3,4-Methylenedioxyphenoxy)phthalonitrile；4-(1,3-benzodioxol-5-yloxy)benzene-1,2-dicarbonitrile
• CAS: 850554-73-3
• 化学式: C₁₅H₈N₂O₃
• 分子量: 264.24
• InChiKey: RQJCIBBOPHNQKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  75.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-[3,4-(methylendioxy)phenoxy]phthalonitrile 、 manganese(II) acetate 在 1,8-diazabicyclo[5.4.0]undec-7-ene 作用下， 以 further solvent(s) 为溶剂， 生成 tetrakis[3,4-(methylenedioxy)phenoxy]phthalocyaninato manganese(III) acetate
  参考文献：
  名称：

  Erdomu, Ali; Akinbulu, Isaac Adebayo; Nyokong, Tebello, Polyhedron, 2010, vol. 29, # 11, p. 2352 - 2363

  摘要：

  DOI：

文献信息

• Novel indium(<scp>iii</scp>) phthalocyanines; synthesis, photophysical and humidity sensing properties
  作者：Bahadır Keskin、Olcay Okuyucu、Ahmet Altındal、Ali Erdoğmuş

  DOI：10.1039/c6nj00057f

  日期：——

  Novel indium(iii) phthalocyanines were synthesized. Photophysical properties and the humidity detection capabilities of their films have also been investigated.

  合成了新型铟（III）酞菁化合物。研究了其薄膜的光物理特性和湿度检测能力。
• CYANOISOQUINOLINE COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Arend Michael

  公开号：US20070298104A1

  公开（公告）日：2007-12-27

  The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoietin-associated conditions. The cyanoisoquinoline compounds of the invention have the following structure:

  本发明涉及适用于治疗缺氧诱导因子介导和/或促红细胞生成素相关疾病的氰基异喹啉化合物。本发明的氰基异喹啉化合物具有以下结构：
• Cyanoisoquinoline Compounds and Methods of Use Thereof
  申请人：Arend Michael P.

  公开号：US20110212959A1

  公开（公告）日：2011-09-01

  The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoietin-associated conditions. The cyanoisoquinoline compounds of the invention have the following structure:

  本发明涉及适用于治疗缺氧诱导因子介导和/或促红细胞生成素相关疾病的氰基异喹啉化合物。本发明的氰基异喹啉化合物具有以下结构：
• Cyanoisoquinoline compounds and methods of use thereof
  申请人：Fibrogen, Inc.

  公开号：EP2476669A1

  公开（公告）日：2012-07-18

  The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoietin-associated conditions. The cyanoisoquinoline compounds of the invention have the following structure:

  本发明涉及适用于治疗缺氧诱导因子介导和/或促红细胞生成素相关疾病的氰基异喹啉化合物。本发明的氰基异喹啉化合物具有如下结构：
• New soluble methylendioxy-phenoxy-substituted zinc phthalocyanine derivatives: Synthesis, photophysical and photochemical studies
  作者：Ali Erdoğmuş、Tebello Nyokong

  DOI：10.1016/j.poly.2009.06.019

  日期：2009.9

  The syntheses of new three phthalonitriles (1, 2 and 3), together with photophysical and photochemical properties of the resulting peripherally and non-peripherally tetrakis- and octakis 3,4-(methylendioxy)-phenoxy-substituted zinc phthalocyanines (4, 5 and 6) are described for the first time. Complexes 4, 5 and 6 have been synthesized and characterized by elemental analysis, IR, H-1 NMR spectroscopy, electronic spectroscopy and mass spectra. Complexes 4, 5 and 6 have good solubility in organic solvents such as CHCl3, DCM, DMSO, DMF, THF and toluene and are mainly not aggregated (except for complex 6 in DMSO) within a wide concentration range. General trends are described for singlet oxygen, photodegradation, fluorescence quantum yields, triplet quantum yields and triplet life times of these complexes in DMSO and toluene. Complex 4 has higher singlet oxygen quantum yields, fluorescence quantum yields, triplet quantum yields and triplet life times than complexes 5 and 6. The effect of the solvents on the photophysical and photochemical parameters of the zinc(II) phthalocyanines (4, 5 and 6) are also reported. (C) 2009 Elsevier Ltd. All rights reserved.