4-[5-(1-methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-furo[2,3-c]pyridin-2-yl]-4-methyl-piperidine-1-carboxylic acid tert-butyl ester | 1451163-55-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-[5-(1-methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-furo[2,3-c]pyridin-2-yl]-4-methyl-piperidine-1-carboxylic acid tert-butyl ester
• 英文别名: 4-[5-(1-Methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-furo[2,3-c]pyridin-2-yl]-4-methyl-piperidine-1-carboxylic acid tert-butyl ester；tert-butyl 4-methyl-4-[5-(1-methylsulfonyl-3,6-dihydro-2H-pyridin-4-yl)furo[2,3-c]pyridin-2-yl]piperidine-1-carboxylate
• CAS: 1451163-55-5
• 化学式: C₂₄H₃₃N₃O₅S
• 分子量: 475.609
• InChiKey: XCGFWKLJULHLIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  1-甲磺酰基-4-(四甲基-1,3,2-二氧杂硼硼烷-2-基)-1,2,3,6-四氢吡啶 、 4-(5-chloro-furo[2,3-c]pyridin-2-yl)-4-methyl-piperidine-1-carboxylic acid tert-butyl ester 生成 4-[5-(1-methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-furo[2,3-c]pyridin-2-yl]-4-methyl-piperidine-1-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  Compounds, pharmaceutical compositions and uses thereof

  摘要：

  本发明涉及公式I的化合物，其中R1、R2和A的基团如申请中所定义，具有有价值的药理学性质，特别是可与GPR119受体结合并调节其活性。

  公开号：

  US09012456B2

文献信息

• [EN] FURO [2, 3 -C] PYRIDINES ACTIVES ON GPR 119<br/>[FR] FURO[2, 3-C]PYRIDINES ACTIVES SUR LE GPR 119
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2013127828A1

  公开（公告）日：2013-09-06

  The present invention relates to compounds of general formula (I), wherein the groups R1, R2, and A are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR1 19 receptor and modulate its activity.

  本发明涉及一般式（I）的化合物，其中基团R1、R2和A如申请中定义，具有有价值的药理特性，特别是结合到GPR119受体并调节其活性。
• NEW COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
  申请人：ECKHARDT Matthias

  公开号：US20130225601A1

  公开（公告）日：2013-08-29

  The present invention relates to compounds of general formula I, wherein the groups R 1 , R 2 , and A are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.

  本发明涉及一般式I的化合物，其中基团R1、R2和A如申请中定义，具有有价值的药理特性，特别是结合到GPR119受体并调节其活性。
• FURO[2,3-C]PYRIDINES ACTIVES ON GPR 119
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2820022B1

  公开（公告）日：2018-01-03
• US9012456B2
  申请人：——

  公开号：US9012456B2

  公开（公告）日：2015-04-21
• Compounds, pharmaceutical compositions and uses thereof
  申请人：Boehringer Ingelheim International GmbH

  公开号：US09012456B2

  公开（公告）日：2015-04-21

  The present invention relates to compounds of general formula I, wherein the groups R1, R2, and A are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.

  本发明涉及公式I的化合物，其中R1、R2和A的基团如申请中所定义，具有有价值的药理学性质，特别是可与GPR119受体结合并调节其活性。