5-Iod-7-amino-8-chinolinol | 18471-95-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-Iod-7-amino-8-chinolinol
• 英文别名: 7-amino-5-iodo-quinolin-8-ol；7-Amino-5-iodo-8-quinolinol；7-amino-5-iodoquinolin-8-ol
• CAS: 18471-95-9
• 化学式: C₉H₇IN₂O
• 分子量: 286.072
• InChiKey: JJCLLNDLDHJDRA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  59.1
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• IDENTIFICATION AND USE OF COMPOUNDS THAT AFFECT THE FIDELITY OF EUKARYOTIC TRANSLATION INITIATION CODON SELECTION
  申请人：Lorsch Jon R.

  公开号：US20110230451A1

  公开（公告）日：2011-09-22

  A screening method for identifying compounds that alter the fidelity with which the initiation codon in mRNAs is recognized by the translational apparatus in eukaryotes is disclosed. This screening method was used to identify compounds having such activity. Methods of altering the fidelity of initiation codon selection are also disclosed. Methods of treating disorders characterized by single nucleotide mutations in initiation codons using compounds identified by the screening method, as well as methods of treating fungal and parasitic infections and hyperproliferative disorders using compounds identified by the screening method are also disclosed.
• US8828976B2
  申请人：——

  公开号：US8828976B2

  公开（公告）日：2014-09-09
• [EN] METHOD FOR TREATING DRUG-RESISTANT BACTERIAL AND OTHER INFECTIONS WITH CLIOQUINOL, PHANQUINONE, AND RELATED COMPOUNDS<br/>[FR] PROCÉDÉ POUR TRAITER DES INFECTIONS BACTÉRIENNES RÉSISTANT AU MÉDICAMENT ET D'AUTRES INFECTIONS PAR DU CLIOQUINOL, DE LA PHANQUINONE ET DES COMPOSÉS APPARENTÉS
  申请人：XILINAS MICHEL E

  公开号：WO2009140215A2

  公开（公告）日：2009-11-19

  The invention relates to new uses of known chelating compounds for the treatment of bacterial in fungal infections, particularly by methicilllin-resistant and other drug-resistant strains of bacteria and fungi. One of more chelating compound is administered with or without additional antibiotic or antifungal drugs to achieve improved therapy. Preferred chelating compounds include clioquinol, 5,7-dichloro-8-hydroxy-quinaldine, phanquinone, 5,7-dichloro-8-hydroxyquinoline, 5,7- di-iodo-8-hydroxyquinoline. By chelation of specific metal ions, these compounds treat any infection by bacteria or fungi whose pathogenicity depends upon metalloenzymes that require these cations. The compounds are also effective against infections caused by extended β lactamase and metallo β lactamase producing bacterial strains. Bacteria targeted by these methods include methicillin-resistant Staphylococcus aureus, penicillin resistant or intermediate resistant Streptococcus pneumoniae and other gram positive and multiresistant gram negative species and strains.