D-半胱氨酸硫内酯盐酸盐 | 1120-77-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: D-半胱氨酸硫内酯盐酸盐
• 英文名称: D-homocysteine thiolactone hydrochloride
• 英文别名: [(3R)-2-oxothiolan-3-yl]azanium;chloride
• CAS: 1120-77-0
• 化学式: C₄H₇NOS*ClH
• mdl: MFCD00077785
• 分子量: 153.633
• InChiKey: ZSEGSUBKDDEALH-AENDTGMFSA-N

物化性质

• 熔点：
  185-187 °C
• 溶解度：
  DMSO（少许）、水（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  -0.25
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  68.4
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2934999090
• 储存条件：
  2-8°C

反应信息

• 作为反应物：
  描述：

  D-半胱氨酸硫内酯盐酸盐 在 碳酸氢钠 作用下， 生成 3,6-Bis(2-sulfanylethyl)-2,5-piperazinedione
  参考文献：
  名称：

  du Vigneaud; Patterson; Hunt, Journal of Biological Chemistry, 1938, vol. 126, p. 217,225

  摘要：

  DOI：
• 作为产物：
  描述：

  DL-高半胱氨酸硫内酯盐酸盐 在 chiral stationary phase including isopropyl-functionalized CF₆ 作用下， 以 乙醇 、 正庚烷 、 三氟乙酸 为溶剂， 生成 D-半胱氨酸硫内酯盐酸盐 、 L-高半胱氨酸硫代内酯盐酸盐
  参考文献：
  名称：

  [EN] COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS
  [FR] COMPOSITIONS ET PROCÉDÉS POUR DES CYCLOFRUCTANES EN TANT QU'AGENTS DE SÉPARATION

  摘要：

  公开号：

  WO2010148191A3

文献信息

• Hydroxamic acid compounds
  申请人：Adir et Compagnie

  公开号：US06063816A1

  公开（公告）日：2000-05-16

  A compound selected from those of formula (I): ##STR1## wherein: R.sub.1 represents optionally substituted alkyl, acyl, cycloalkyl, aryl, aminocarbonylalkyl, or heterocycle, R.sub.2 represents alkylene, R.sub.3 represents X or Y as defined in the description, R.sub.4 represents--either alkyl, cycloalkyl, aryl, arylalkyl, cycloalkylalkyl, heterocycloalkylene, or heterocycle when R.sub.3 represents Y, or biaryl, arylheteroaryl or heteroarylaryl, when R.sub.3 represents X or Y, their isomers and also pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful as metalloprotease inhibitors in the treatment of cancers.

  从公式（I）中选择的化合物：##STR1##其中：R.sub.1代表可选择的取代基烷基，酰基，环烷基，芳基，氨基羰基烷基或杂环；R.sub.2代表亚烷基；R.sub.3代表描述中定义的X或Y；当R.sub.3代表Y时，R.sub.4代表-烷基，环烷基，芳基，芳基烷基，环烷基烷基，杂环烷基或杂环；当R.sub.3代表X或Y时，R.sub.4代表双芳基，芳基杂芳基或杂芳基芳基，它们的异构体以及其药学上可接受的酸或碱盐，以及含有它们的药物制剂，在治疗癌症中用作金属蛋白酶抑制剂。
• Therapeutic heterocycles
  申请人：Cheng Yun-Xing

  公开号：US20050245503A1

  公开（公告）日：2005-11-03

  Compounds of formula (I) or (II) wherein R 1 , R 2 , R 3 , R 4 , W, Q, G, X and Y are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

  本发明提供了式(I)或(II)的化合物，其中R1、R2、R3、R4、W、Q、G、X和Y如规范中所定义，以及所述化合物的盐、对映体和包括所述化合物的药物组合物。它们在治疗中非常有用，特别是在疼痛管理方面。
• Process for the resolution of homocysteine-thiolactone
  申请人：EDMOND PHARMA S.R.L.

  公开号：EP1964838B1

  公开（公告）日：2009-12-30
• Inglesi; Nicola; Fregnan, Il Farmaco, 1994, vol. 40, # 11, p. 703 - 708
  作者：Inglesi、Nicola、Fregnan、Bradamante、Pagani

  DOI：——

  日期：——
• Supercritical Fluid Synthesis and On-Line Preparative Supercritical Fluid Chromatography of 11C-Labelled Compounds in Supercritical Ammonia.
  作者：Gunilla B. Jacobson、Karin E. Markides、Bengt Långström、Erik Jonas Pedersen、Elemér Fogassy、Charles A. McAuliffe、Stenbjörn Styring、Cecilia Tommos、Kurt Warncke、Bryan R. Wood

  DOI：10.3891/acta.chem.scand.51-0418

  日期：——

  An automated supercritical fluid synthesis (SFS) system, designed for reaction and on-line preparative supercritical fluid chromatography (SFC) of C-11-labelled (t(1/2) = 20.3 min) compounds in supercritical ammonia, is described. The synthesis and on-line SFC purification of [methyl-C-11]anisole, L-[methyl-C-11]methionine and 4-methoxyphenyl[C-11]guanidine gave a >98% radiochemically pure product within 30 min. [methyl-C-11]Anisole was obtained from reaction of phenol with [C-11]methyl iodide and was used as a model reaction to evaluate the synthetic procedure of the system. 4-Methoxyphenyl[C-11]guanidine was produced by reaction of p-anisidine with [C-11]cyanogen bromide to give the C-11-labelled cyanamide, followed by reaction with ammonia to obtain the C-11-guanidine compound. Both D- and L-[methyl-C-11]methionine were produced by reaction of [C-11]methyl iodide and D- and L-homocysteine thiolactone hydrochloride, respectively. The effect of base concentration on the radiochemical yield and enantiomeric purity of C-11-methionine was investigated, and it was found that 2.5 equiv. of base gave a radiochemical yield >95% with 2-3% racemization. In a typical synthesis and on-line SFC purification of C-11-methionine, a 5 mu A h (45 mu A, 6.6 min) bombardment to produce [C-11]carbon dioxide gave a 3.1 GBq sterile solution of C-11-methionine.