D-来苏-己-5-酮糖酸 | 13425-76-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 中文名称: D-来苏-己-5-酮糖酸
• 英文名称: D-lyxo-hex-5-ulosonic acid
• 英文别名: 5-keto-D-mannonic acid；D-lyxo-[5]hexulosonic acid；D-lyxo-[5]Hexulosonsaeure；lyxo-5-hexulosonic acid；(2S,3S,4S)-2,3,4,6-tetrahydroxy-5-oxohexanoic acid
• CAS: 13425-76-8
• 化学式: C₆H₁₀O₇
• 分子量: 194.141
• InChiKey: IZSRJDGCGRAUAR-WISUUJSJSA-N

物化性质

• 沸点：
  650.9±55.0 °C(Predicted)
• 密度：
  1.757±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  135
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  D-甘露糖 在 水 、 溴 作用下， 生成 D-来苏-己-5-酮糖酸
  参考文献：
  名称：

  The Isolation of Keturonic Acids as Crystalline Alkaloidal Salts

  摘要：

  DOI：

  10.1021/ja01876a052

文献信息

• Synthesis of Furandicarboxylic Acid Esters From Nonfood Feedstocks Without Concomitant Levulinic Acid Formation
  作者：Frits van der Klis、Jacco van Haveren、Daan S. van Es、Johannes H. Bitter

  DOI：10.1002/cssc.201700051

  日期：2017.4.10

  5-dicarboxylic acid (FDCA). Here, a new strategy for obtaining furans is presented, bypassing the formation of the unstable HMF. Instead of starting with glucose/fructose and thus forming HMF as an intermediate, the new route starts from uronic acids, which are abundantly present in many agro residues such as sugar beet pulp, potato pulp, and citrus peels. Conversion of uronic acids, via ketoaldonic acids, to

  5-羟甲基糠醛（HMF）是生物质转化途径中的通用中间体。然而，众所周知，HMF的不稳定性质给设计选择性路线提供了挑战，这些路线设计了诸如呋喃-2,5-二羧酸（FDCA）之类的化学物质。在这里，提出了一种获得呋喃的新策略，绕过了不稳定的HMF的形成。新途径不是从葡萄糖/果糖开始，从而形成HMF作为中间体，而是从糖醛酸开始，糖醛酸广泛存在于许多农业残留物中，如甜菜浆，马铃薯浆和柑桔皮。经由酮醛酸将糖醛酸转化为中间体甲酰基糠酸（FFA）酯，然后转化为FDCA酯，而不会形成乙酰丙酸或不溶性腐殖质。
• Bioavailability and improved delivery of alkaline pharmaceutical drugs
  申请人：——

  公开号：US20040214215A1

  公开（公告）日：2004-10-28

  Embodiments of the invention relate to a composition, a process of making the composition, and to the use of the composition. The compositions include a molecular complex formed between an alkaline pharmaceutical drug and at least one selected from a hydroxyacid, a polyhydroxy acid, a related acid, a lactone, or combinations thereof. The compositions provide improved bioavailability and improved delivery of the drug into the cutaneous tissues.

  本发明实施例涉及一种组合物、制备该组合物的过程以及使用该组合物。该组合物包括碱性药物和至少一种选择自羟酸、多羟酸、相关酸、内酯或其组合物的分子复合物。该组合物提供了改善的生物利用度和将药物输送至皮肤组织的改善输送。
• Urea composition
  申请人：——

  公开号：US20040033963A1

  公开（公告）日：2004-02-19

  The invention is directed to compositions, methods of making the compositions, and methods of treating cosmetic and dermatological disorders with a composition that includes a molecular complex between urea and a functional substance that has at least one hydroxyl group and one carboxyl group either as a free acid, a salt, an amide or a lactone. The compositions are stable when compared to conventional urea-containing compositions, and provide controlled-release of the urea.

  本发明涉及组合物、组合物的制造方法以及用组合物治疗化妆品和皮肤病的方法，该组合物包括尿素与一种功能物质之间的分子络合物，该功能物质具有至少一个羟基和一个羧基，可以是游离酸、盐、酰胺或内酯。与传统的含尿素组合物相比，这种组合物非常稳定，并能控制尿素的释放。
• Enlargement of mucocutaneous or cutaneous organs and sites with topical compositions
  申请人：Yu J. Ruey

  公开号：US20050171194A1

  公开（公告）日：2005-08-04

  Compositions comprising a hydroxycarboxylic acid, N-acyl-aldosamine, N-acylamino acid or related compound on topical application are beneficial to plump and pout lips, enhance and firm eyelids, enlarge and augment breasts, elongate and expand penis. Because of antioxidant property, certain hydroxycarboxylic acids, N-acyl-aldosamines, N-acylamino acids and related compounds also are useful for topical administration to prevent occurrence of breast cancer or other forms of tumors and cancers.

  由羟基羧酸、N-酰基-醛糖胺、N-酰基氨基酸或相关化合物组成的组合物在局部使用时有利于丰满嘴唇、增强和紧实眼睑、增大和隆起乳房、拉长和扩张阴茎。由于具有抗氧化性，某些羟基羧酸、N-酰基醛胺和 N-酰基氨基酸及相关化合物还可用于局部用药，以预防乳腺癌或其他形式的肿瘤和癌症的发生。
• Regio- and stereo-selectivity in homogeneous catalytic hydrogenation of 2,5-diketo-d-threo-hexonic acid
  作者：Zdenko Hameršak、Nediljko Pavlović、Vladimir Delić、Vitomir Šunjić

  DOI：10.1016/s0008-6215(97)00121-3

  日期：1997.8

  2,5-Diketo-D-threo-hexonic acid (2,5-diketo-D-gluconic acid, 1), a crucial intermediate in the microbial production of L-threo-hex-2-enono-1,4-lactone (L-ascorbic acid, vitamin C), was isolated from the fermentation broth of bacterium Erwinia citreus ATCC 31623, and its regio-and stereo-selective hydrogenation, catalyzed by the water-soluble Ru(LT) complex of tris(m-sulfophenyl)phosphine (TPPTS), was performed. The effect of hydrogen pressure, temperature, pH, and catalyst-to-substrate ratio on regio-and stereo-selectivity of the process was studied. At low pH, over 90% regioselectivity in favor of the reduction of the 5-keto group in 1 was achieved, affording L-xylo-2-hexulosonic acid (2-keto-L-gulonic acid, 2) as the main product. Maximal diastereoselectivity, i.e. ratio between 2 and 2-keto-D-gulonic acid (3) expressed as diastereomeric excess (d.e.%), amounted to ca. 50% and was not influenced by any of the above reaction parameters. (C) 1997 Published by Elsevier Science Ltd.