申请人:TAKARA BIO INC.
公开号:EP1312670A1
公开(公告)日:2003-05-21
The present invention provides methods for inducing, maintaining and expanding CTL (cytotoxic T cell) having an antigen-specific cytotoxic activity at a high level, which is useful in the adoptive immunotherapy, by using as an effective ingredient at least one compound selected from the group consisting of acidic polysaccharides, acidic oligosaccharides, acidic monosaccharides, and salts thereof. The above-mentioned compounds include fucoidans, heparins, alginic acid, chondroitin sulfate A, chondroitin sulfate B, pectic acid, hyaluronic acid, degradation products of fucoidans, sulfated glucose, sulfated fucose and salts thereof.
本发明提供了通过使用至少一种选自酸性多糖、酸性寡糖、酸性单糖及其盐组成的组的化合物作为有效成分,诱导、维持和扩增具有高水平抗原特异性细胞毒性活性的CTL(细胞毒性T细胞)的方法,这在采用性免疫疗法中是有用的。上述化合物包括褐藻糖、肝素、海藻酸、硫酸软骨素 A、硫酸软骨素 B、果胶酸、透明质酸、褐藻糖的降解产物、硫酸化葡萄糖、硫酸化岩藻糖及其盐类。