1-Methyl-3-nitro-1,2,3,4-tetrahydroquinoline-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-Methyl-3-nitro-1,2,3,4-tetrahydroquinoline-2,4-dione
• 英文别名: 1-methyl-3-nitroquinoline-2,4-dione
• 化学式: C10H8N2O4
• 分子量: 220.18
• InChiKey: UNWGBPXMJLXDOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  83.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• SUBSTITUTED BICYCLIC COMPOUNDS USEFUL AS T CELL ACTIVATORS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20210188845A1

  公开（公告）日：2021-06-24

  Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR 6 or N; Y is CR 3 or N; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

  揭示了Formula (I)的化合物： 或其盐，其中：X为CR 6 或N；Y为CR 3 或N；R 1 ，R 2 ，R 3 ，R 4 ，R 5 ，R 6 ，R 7 和m在此处定义。还揭示了使用这些化合物来抑制二酰甘油激酶α（DGKα）和二酰甘油激酶ζ（DGKζ）中的一个或两个活性的方法，以及包含这些化合物的药物组合物。这些化合物在治疗病毒感染和增生性疾病（如癌症）方面是有用的。
• [EN] SUBSTITUTED HETEROARYL COMPOUNDS USEFUL AS T CELL ACTIVATORS<br/>[FR] COMPOSÉS HÉTÉROARYLE SUBSTITUÉS UTILES EN TANT QU'ACTIVATEURS DE LYMPHOCYTES T
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2021133752A1

  公开（公告）日：2021-07-01

  Disclosed are compounds of Formula (I): (I) or a salt thereof, wherein: X is CR6 or N; Y is CR3 or N; R1, R2, R3, R4, R5, R6, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

  本发明涉及以下式(I)的化合物或其盐，其中：X是CR6或N；Y是CR3或N；R1，R2，R3，R4，R5，R6和m的定义如下。本发明还涉及使用这些化合物来抑制二酰甘油激酶α（DGKα）和二酰甘油激酶ζ（DGKζ）中的一个或两个的活性的方法，以及包含这些化合物的制药组合物。这些化合物在治疗病毒感染和增生性疾病，如癌症中有用。
• SUBSTITUTED HETEROARYL COMPOUNDS USEFUL AS T CELL ACTIVATORS
  申请人：Bristol-Myers Squibb Company

  公开号：EP4081524A1

  公开（公告）日：2022-11-02
• [EN] SUBSTITUTED BICYCLIC PIPERIDINE DERIVATIVES USEFUL AS T CELL ACTIVATORS<br/>[FR] DÉRIVÉS DE PIPÉRIDINE BICYCLIQUES SUBSTITUÉS UTILES EN TANT QU'ACTIVATEURS DE LYMPHOCYTES T
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2021133750A1

  公开（公告）日：2021-07-01

  Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR6 or N; Y is CR3 or N; R1, R2, R3, R4, R5, R6, R7, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.