D-葡萄糖胺氢碘化 | 14999-44-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: D-葡萄糖胺氢碘化
• 中文别名: 2-氨基-2-脱氧-D-葡萄糖氢碘酸盐；氨基葡萄糖盐酸盐
• 英文名称: 2-Amino-2-deoxy-D-glucose hydroiodide
• 英文别名: (2R,3R,4S,5R)-2-amino-3,4,5,6-tetrahydroxyhexanal;hydroiodide
• CAS: 14999-44-1
• 化学式: C6H14INO5
• 分子量: 307.08
• InChiKey: CAOFVLJHCHGTGE-BTVCFUMJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.79
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  124
• 氢给体数：
  6
• 氢受体数：
  6

文献信息

• Double salts of (-)-hydroxycitric acid with an amine and a group II a metal and a process for preparing the same
  申请人：Gokaraju R. Ganga

  公开号：US20070027110A1

  公开（公告）日：2007-02-01

  This invention relates to novel double salt of (−)-hydroxycitric acid with an amine and zinc or a group II A metal. These compounds are stable and water soluble and are used as nutraceuticals, weight reducing agents and in beverages. The double salts have the following general formula (I) Wherein X is zinc or a metal belonging to group II A of the Periodic Table and Y is glucosamine, caffeine or a known anorexic amine residue.

  这项发明涉及(-)-羟基柠檬酸与胺和锌或II A族金属的新型双盐。这些化合物稳定且水溶性，可用作保健品、减肥剂和饮料。双盐具有以下一般式(I)，其中X为锌或周期表II A族金属，Y为葡萄糖胺、咖啡因或已知的厌食胺残基。
• Method for the treatment and prevention of pain and inflammation with glucosamine and a cyclooxygenase-2 selective inhibitor and compositions therefor
  申请人：Pharmacia Corporation

  公开号：US20030114418A1

  公开（公告）日：2003-06-19

  A method of treating, preventing, or inhibiting pain, inflammation or inflammation-associated disorder in a subject in need of such treatment or prevention provides for treating the subject with glucosamine and a cyclooxygenase-2 selective inhibitor or prodrug thereof, wherein the amount of glucosamine and the amount of a cyclooxygenase-2 selective inhibitor or prodrug thereof together constitute a pain or inflammation suppressing treatment or prevention effective amount of the composition. Compositions and pharmaceutical compositions that contain glucosamine and a cyclooxygenase-2 selective inhibitor are also disclosed.

  一种治疗、预防或抑制需要此类治疗或预防的受试者的疼痛、炎症或与炎症相关疾病的方法包括使用氨基葡萄糖和环氧合酶-2选择性抑制剂或其前药来治疗受试者，其中氨基葡萄糖的量和环氧合酶-2选择性抑制剂或其前药的量共同构成组合物的疼痛或炎症抑制治疗或预防的有效量。还公开了含有氨基葡萄糖和环氧合酶-2选择性抑制剂的组合物和药物组合物。
• Method and compositions for the treatment and prevention of pain and inflammation with a cyclooxygenase-2 selective inhibitor and chondroitin sulfate
  申请人：Pharmacia Corporation

  公开号：US20030114416A1

  公开（公告）日：2003-06-19

  A method of treating, preventing, or inhibiting pain, inflammation or inflammation-associated disorder in a subject in need of such treatment or prevention provides for treating the subject with chondroitin sulfate and a cyclooxygenase-2 selective inhibitor, or a prodrug thereof, wherein the amount of chondroitin sulfate and the amount of a cyclooxygenase-2 selective inhibitor or a pharmaceutically acceptable salt or prodrug thereof together constitute a pain or inflammation suppressing treatment or prevention effective amount. Glucosamine can optionally be present. Compositions that contain the combination of chondroitin sulfate and cyclooxygenase-2 selective inhibitor and, optionally, the glucosamine, are disclosed, as are pharmaceutical compositions.

  一种治疗、预防或抑制疼痛、炎症或与炎症相关疾病的方法，适用于需要此类治疗或预防的受试者，包括使用软骨素硫酸和环氧合酶-2选择性抑制剂或其前药来治疗受试者，其中软骨素硫酸的数量和环氧合酶-2选择性抑制剂或其药用可接受的盐或前药的数量共同构成有效的疼痛或炎症抑制治疗或预防量。可选择添加氨基葡萄糖。公开了含有软骨素硫酸和环氧合酶-2选择性抑制剂以及可选地氨基葡萄糖的组合的组合物，以及药物组合物。
• Method and compositions for the treatment and prevention of pain and inflammation
  申请人：Pulaski P. Steven

  公开号：US20050101563A1

  公开（公告）日：2005-05-12

  A method of preventing or treating pain or inflammation in a subject is provided by administering to the subject a Cox-2 inhibitor and a polyunsaturated fatty acid, or a prodrug thereof, wherein the amount of a Cox-2 inhibitor and polyunsaturated fatty acid or a pharmaceutically acceptable salt or prodrug thereof together constitute a pain or inflammation suppressing treatment or prevention effective amount. Glucosamine and/or chondroitin can optionally be present. Therapeutic compositions that contain the combination of Cox-2 inhibitor and polyunsaturated fatty acid and, optionally, the glucosamine and/or chondroitin, are disclosed, as are pharmaceutical compositions.

  本方法提供了一种预防或治疗受试者疼痛或炎症的方法，通过向受试者施用Cox-2抑制剂和多不饱和脂肪酸，或其前药，其中Cox-2抑制剂和多不饱和脂肪酸或其药用盐或前药的数量共同构成疼痛或炎症抑制治疗或预防有效量。可选择添加葡萄糖胺和/或软骨素。公开了包含Cox-2抑制剂和多不饱和脂肪酸以及可选的葡萄糖胺和/或软骨素的治疗组合，以及药用组合物。
• Process and materials for production of glucosamine and N-acetylglucosamine
  申请人：——

  公开号：US20040091976A1

  公开（公告）日：2004-05-13

  A biosynthetic method for producing glucosamine and N-acetylglucosamine is disclosed. Such a method includes the fermentation of a genetically modified microorganism to produce glucosamine and/or N-acetylglucosamine. Also disclosed are genetically modified microorganisms that are useful for producing glucosamine and N-acetylglucosamine. In addition, methods of recovering N-acetylglucosamine that has been produced by a fermentation process, including methods that result in N-acetylglucosamine of high purity, are described. Also disclosed is a method to produce glucosamine from N-acetylglucosamine.

  本发明公开了一种生物合成法，用于生产葡萄糖胺和N-乙酰葡萄糖胺。这种方法包括发酵经过基因改造的微生物以产生葡萄糖胺和/或N-乙酰葡萄糖胺。此外，还公开了用于生产葡萄糖胺和N-乙酰葡萄糖胺的基因改造微生物。此外，还描述了通过发酵过程生产的N-乙酰葡萄糖胺的回收方法，包括导致高纯度N-乙酰葡萄糖胺的方法。还公开了一种从N-乙酰葡萄糖胺中生产葡萄糖胺的方法。