6-[methyl-(2-methylphenyl)sulfamoyl]-4-oxo-1H-quinoline-3-carboxylic Acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-[methyl-(2-methylphenyl)sulfamoyl]-4-oxo-1H-quinoline-3-carboxylic Acid
• 化学式: C₁₈H₁₆N₂O₅S
• mdl: MFCD25949594
• 分子量: 372.4
• InChiKey: XKPFQOBZDFZXHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• COMPOUNDS HAVING ACTIVITY IN INCREASING ION TRANSPORT BY MUTANT-CFTR AND USES THEREOF
  申请人：The Regents of the University of California

  公开号：EP1765347A2

  公开（公告）日：2007-03-28
• EP1765347A4
  申请人：——

  公开号：EP1765347A4

  公开（公告）日：2008-10-01
• Compounds Having Activity in Increasing Ion Transport by Mutant-Cftr and Uses Thereof
  申请人：Verkman Alan

  公开号：US20080319008A1

  公开（公告）日：2008-12-25

  The invention provides compositions, pharmaceutical preparations and methods for increasing activity (e.g., ion transport) of the mutant cystic fibrosis transmembrane conductance regulator protein (mutant-CFTR), e.g., ΔF508 CFTR, G551D-CFTR, G1349D-CFTR, or D1152H-CFTR, that are useful for the treatment of cystic fibrosis (CF). The compositions and pharmaceutical preparations of the invention may comprise one or more phenylglycine-containing compounds or sulfonamide-containing compounds of the invention, or an analog or derivative thereof.
• [EN] COMPOUNDS HAVING ACTIVITY IN INCREASING ION TRANSPORT BY MUTANT-CFTR AND USES THEREOF<br/>[FR] COMPOSES INTERVENANT DANS L'ACCELERATION DU TRANSPORT IONIQUE PAR LE CFTR MUTANT, ET UTILISATIONS DESDITS COMPOSES
  申请人：UNIV CALIFORNIA

  公开号：WO2005120497A2

  公开（公告）日：2005-12-22

  The invention provides compositions, pharmaceutical preparations and methods for increasing activity (e.g., ion transport) of the mutant cystic fibrosis transmembrane conductance regulator protein (mutant-CFTR), e.g., DF508 CFTR, G551D-CFTR, G1349D-CFTR, or D1152H-CFTR, that are useful for the treatment of cystic fibrosis (CF). The compositions and pharmaceutical preparations of the invention may comprise one or more phenylglycine-containing compounds or sulfonamide-containing compounds of the invention, or an analog or derivative thereof.