6-[Methyl(2-methylphenyl)sulfamoyl]-N-(3-methylbutyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-[Methyl(2-methylphenyl)sulfamoyl]-N-(3-methylbutyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide
• 英文别名: N-(3-methylbutyl)-6-[methyl-(2-methylphenyl)sulfamoyl]-4-oxo-1H-quinoline-3-carboxamide
• 化学式: C₂₃H₂₇N₃O₄S
• mdl: MFCD15097149
• 分子量: 441.5
• InChiKey: GBRTYORXUGAGFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Compounds Having Activity in Increasing Ion Transport by Mutant-Cftr and Uses Thereof
  申请人：Verkman Alan

  公开号：US20080319008A1

  公开（公告）日：2008-12-25

  The invention provides compositions, pharmaceutical preparations and methods for increasing activity (e.g., ion transport) of the mutant cystic fibrosis transmembrane conductance regulator protein (mutant-CFTR), e.g., ΔF508 CFTR, G551D-CFTR, G1349D-CFTR, or D1152H-CFTR, that are useful for the treatment of cystic fibrosis (CF). The compositions and pharmaceutical preparations of the invention may comprise one or more phenylglycine-containing compounds or sulfonamide-containing compounds of the invention, or an analog or derivative thereof.
• Compounds Having Activity in Increasing Ion Transport by Mutant-CFTR and Uses Thereof
  申请人：Verkman Alan

  公开号：US20120101143A1

  公开（公告）日：2012-04-26

  The invention provides compositions, pharmaceutical preparations and methods for increasing activity (e.g., ion transport) of the mutant cystic fibrosis transmembrane conductance regulator protein (mutant-CFTR), e.g., DF508 CFTR, G551D-CFTR, G1349D-CFTR, or D1152H-CFTR, that are useful for the treatment of cystic fibrosis (CF). The compositions and pharmaceutical preparations of the invention may comprise one or more phenylglycine-containing compounds or sulfonamide-containing compounds of the invention, or an analog or derivative thereof.
• US7939558B2
  申请人：——

  公开号：US7939558B2

  公开（公告）日：2011-05-10