1H-Imidazole, 2-(2,5-dimethylphenyl)- | 1314972-83-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1H-Imidazole, 2-(2,5-dimethylphenyl)-
• 英文别名: 2-(2,5-dimethylphenyl)-1H-imidazole
• CAS: 1314972-83-2
• 化学式: C₁₁H₁₂N₂
• mdl: MFCD08668898
• 分子量: 172.23
• InChiKey: PIMKIGMIMGQVJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.181
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  烟酰氯 、 1H-Imidazole, 2-(2,5-dimethylphenyl)- 以 乙醚 为溶剂， 反应 24.0h， 生成 [2-(2,5-dimethylphenyl)-imidazol-1-yl]pyridin-3-ylmethanone
  参考文献：
  名称：

  Synthesis, antimicrobial and antimycobacterial evaluation of [2-(substituted phenyl)-imidazol-1-yl]-pyridin-3-yl-methanones

  摘要：

  A series of [2-(substituted phenyl)-imidazol-1-yl]-pyridin-3-yl-methanones (1-11) were synthesized and screened for their antimicrobial and antimycobacterial activities. Further, a series of [2-(substituted phenyl)-benzimidazol-1-yl]-pyridin-3-yl-methanones (12-20) reported in our earlier study was also screened for their antimycobacterial activity. The antimycobacterial activity results indicated that [2-(4-Nitro-phenyl)-imidazol-1-yl]-pyridin-3-yl-methanone (8, minimum inhibitory concentration [MIC] = 3.13 mu g) was equipotent as standard drug ciprofloxacin and [2-(4-Nitrophenyl)-benzimidazol-1-yl]-pyridin-3-yl-methanone (16, MIC = 1.56 mu g) was equipotent as standard drug ethambutol. The results of antimicrobial screening demonstrated that 2-[1-(Pyridine-3-carbonyl)-1H-imidazol-2-yl]-benzoic acid (compound 11, MIC = 0.002 mu g) was two times more effective than standard drug ciprofloxacin (MIC = 0.004 mu g) against tested bacterial strains and [2-(2,5-Dimethyl-phenyl)-imidazol-1-yl]-pyridin-3-yl-methanone (compound 3, MIC = 0.005 mu g) was equipotent to the reference compound, fluconazole against tested fungal strains.

  DOI：

  10.3109/14756366.2010.548331
• 作为产物：
  描述：

  咪唑 、 2,5-二甲基苯胺 在 盐酸 、 sodium azide 、 sodium acetate 作用下， 以 水 为溶剂， 反应 51.0h， 生成 1H-Imidazole, 2-(2,5-dimethylphenyl)-
  参考文献：
  名称：

  Synthesis, antimicrobial and antimycobacterial evaluation of [2-(substituted phenyl)-imidazol-1-yl]-pyridin-3-yl-methanones

  摘要：

  A series of [2-(substituted phenyl)-imidazol-1-yl]-pyridin-3-yl-methanones (1-11) were synthesized and screened for their antimicrobial and antimycobacterial activities. Further, a series of [2-(substituted phenyl)-benzimidazol-1-yl]-pyridin-3-yl-methanones (12-20) reported in our earlier study was also screened for their antimycobacterial activity. The antimycobacterial activity results indicated that [2-(4-Nitro-phenyl)-imidazol-1-yl]-pyridin-3-yl-methanone (8, minimum inhibitory concentration [MIC] = 3.13 mu g) was equipotent as standard drug ciprofloxacin and [2-(4-Nitrophenyl)-benzimidazol-1-yl]-pyridin-3-yl-methanone (16, MIC = 1.56 mu g) was equipotent as standard drug ethambutol. The results of antimicrobial screening demonstrated that 2-[1-(Pyridine-3-carbonyl)-1H-imidazol-2-yl]-benzoic acid (compound 11, MIC = 0.002 mu g) was two times more effective than standard drug ciprofloxacin (MIC = 0.004 mu g) against tested bacterial strains and [2-(2,5-Dimethyl-phenyl)-imidazol-1-yl]-pyridin-3-yl-methanone (compound 3, MIC = 0.005 mu g) was equipotent to the reference compound, fluconazole against tested fungal strains.

  DOI：

  10.3109/14756366.2010.548331

文献信息

• 5,5-FUSED ARYLENE OR HETEROARYLENE HEPATITIS C VIRUS INHIBITORS
  申请人：IDENIX Pharmaceuticals, Inc.

  公开号：EP2513113A1

  公开（公告）日：2012-10-24
• METHODS FOR TREATING DRUG-RESISTANT HEPATITIS C VIRUS INFECTION WITH A 5,5-FUSED ARYLENE OR HETEROARYLENE HEPATITIS C VIRUS INHIBITOR
  申请人：IDENIX Pharmaceuticals, Inc.

  公开号：EP2691093A1

  公开（公告）日：2014-02-05
• POLISHING COMPOSITION
  申请人：FUJIMI INCORPORATED

  公开号：US20150069016A1

  公开（公告）日：2015-03-12

  There is provided a polishing composition capable of suppressing formation of a stepped portion caused by etching of a surface of a polishing object including a portion containing a group IV material when the polishing object is polished. The present invention relates to a polishing composition for polishing of a polishing object including a portion that contains a group IV material, and the polishing composition contains an oxidizing agent and an anticorrosive agent. Preferably, the anticorrosive agent includes at least one selected from the group consisting of compounds in which two or more carbonyl groups contained in a molecule are bonded through a carbon atom in the molecule. To be more specific, preferably, the anticorrosive agent includes at least one selected from the group consisting of a 1,3-diketone compound, a 1,4-diketone compound, and a triketone compound.
• US9376594B2
  申请人：——

  公开号：US9376594B2

  公开（公告）日：2016-06-28
• [EN] 5,5-FUSED ARYLENE OR HETEROARYLENE HEPATITIS C VIRUS INHIBITORS<br/>[FR] INHIBITEURS DU VIRUS DE L'HÉPATITE C À BASE DE 5,5-ARYLÈNE OU HÉTÉROARYLÈNE CONDENSÉ
  申请人：IDENIX PHARMACEUTICALS INC

  公开号：WO2011075615A1

  公开（公告）日：2011-06-23

  Provided herein are 5,5-fused heteroarylene hepatitis C virus inhibitor compounds, for example, of Formula I, IA, or IB, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof. Formula (I), (IA), (IB).