ethyl 2-(N,N-bis-Boc)amino-4-oxazolecarboxylate | 566206-02-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ethyl 2-(N,N-bis-Boc)amino-4-oxazolecarboxylate
• 英文别名: Ethyl 2-[bis[(2-methylpropan-2-yl)oxycarbonyl]amino]-1,3-oxazole-4-carboxylate
• CAS: 566206-02-8
• 化学式: C₁₆H₂₄N₂O₇
• 分子量: 356.376
• InChiKey: AZOGRYMJFHKVCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  108
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  ethyl 2-(N,N-bis-Boc)amino-4-oxazolecarboxylate 在 三氟乙酸 作用下， 生成 Ethyl 2-(Boc-amino)oxazole-4-carboxylate
  参考文献：
  名称：

  The Synthesis of Aminoazole Analogs of Lysine and Arginine: The Mitsunobu Reaction with Lysinol and Argininol

  摘要：

  DOI：

  10.1055/s-1999-2819
• 作为产物：
  描述：

  乙基3-氯-2-氧代丙酸酯 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 生成 ethyl 2-(N,N-bis-Boc)amino-4-oxazolecarboxylate
  参考文献：
  名称：

  The Synthesis of Aminoazole Analogs of Lysine and Arginine: The Mitsunobu Reaction with Lysinol and Argininol

  摘要：

  DOI：

  10.1055/s-1999-2819

文献信息

• TRICYCLIC SPIROCYCLE DERIVATIVES AND METHODS OF USE
  申请人：McCormick Kevin D.

  公开号：US20110166124A1

  公开（公告）日：2011-07-07

  The present invention relates to novel Tricyclic Spirocycle Derivatives, pharmaceutical compositions comprising the Tricyclic Spirocycle Derivatives and the use of these compounds for treating or preventing allergy, an allergy-induced airway response, congestion, a cardiovascular disease, an inflammatory disease, a gastrointestinal disorder, a neurological disorder, a metabolic disorder, obesity or an obesity-related disorder, diabetes, a diabetic complication, impaired glucose tolerance or aired fasting glucose.

  本发明涉及新型三环螺环衍生物，包括该三环螺环衍生物的药物组合物，以及利用这些化合物治疗或预防过敏、过敏引起的气道反应、充血、心血管疾病、炎症性疾病、消化系统紊乱、神经系统紊乱、代谢紊乱、肥胖或与肥胖相关的疾病、糖尿病、糖尿病并发症、糖耐量受损或空腹血糖异常。
• N-pyrazinyl-phenylsulphonamides and their use in the treatment of chemokine mediated diseases
  申请人：Baxter Andrew

  公开号：US20060025423A1

  公开（公告）日：2006-02-02

  The invention provides N-pyrazinyl-phenyl-sulphonamides of formula (I) for use in the treatment of chemokine mediated diseases. Particularly inflammatory diseases, such as asthma.

  本发明提供了式(I)的N-吡嗪基苯基磺酰胺，用于治疗趋化因子介导的疾病，特别是炎症性疾病，如哮喘。
• [EN] TRICYCLIC SPIROCYCLE DERIVATIVES AND METHODS OF USE THEREOF<br/>[FR] DÉRIVÉS SPIROCYCLIQUES TRICYCLIQUES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：SCHERING CORP

  公开号：WO2010027567A2

  公开（公告）日：2010-03-11

  The present invention relates to novel Tricyclic Spirocycle Derivatives, pharmaceutical compositions comprising the Tricyclic Spirocycle Derivatives and the use of these compounds for treating or preventing allergy, an allergy-induced airway response, congestion, a cardiovascular disease, an inflammatory disease, a gastrointestinal disorder, a neurological disoder, a metabolic disorder, obesity or an obesity-related disorder, diabetes, a diabetic complication, impaired glucose tolerance or impaired fasting glucose.