3-(pyridin-4-ylamino)-1H-indole-2-carboxylic acid (benzenesulfonyl-methyl-amino)-methyl ester | 618889-08-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(pyridin-4-ylamino)-1H-indole-2-carboxylic acid (benzenesulfonyl-methyl-amino)-methyl ester
• 英文别名: [benzenesulfonyl(methyl)amino]methyl 3-(pyridin-4-ylamino)-1H-indole-2-carboxylate
• CAS: 618889-08-0
• 化学式: C₂₂H₂₀N₄O₄S
• 分子量: 436.491
• InChiKey: UUMZYHNMONWXOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3-(4-pyridinylamino)-1H-indole-2-carboxylic acid potassium salt 、 N,N-二甲基甲酰胺 、 N-chloromethyl-N-methyl-4-methylbenzenesulfonamide 、 水 在 氮气 、 二氯甲烷 、 碳酸氢钠 、 水 、 Brine 、 Sodium sulfate-III 、 silica gel 、 ethyl acetate heptane 、 乙酸乙酯 、 甲醇 、 乙醚 作用下， 以 四氢呋喃 为溶剂， 反应 0.33h， 以to obtain the title compound as a white solid (800 mg)的产率得到3-(pyridin-4-ylamino)-1H-indole-2-carboxylic acid (benzenesulfonyl-methyl-amino)-methyl ester
  参考文献：
  名称：

  Interleukin-4 gene expression inhibitors

  摘要：

  本发明揭示和声明了一类吲哚和苯并(b)噻吩衍生物，用于治疗过敏、哮喘、鼻炎、皮炎、B细胞淋巴瘤、肿瘤以及与细菌、鼻病毒或呼吸道合胞病毒(RSV)感染相关的疾病。本发明的化合物由式(I)定义：其中X、Y、Z、R1、R2和R3如规范中所定义；或其药学上可接受的盐。在本发明的优选实施方式中，还揭示和声明本发明的化合物能够调节T辅助细胞(Th)、Th1/Th2，并能够抑制白细胞介素-4(IL-4)信息的转录，IL-4的释放或IL-4的产生。

  公开号：

  US20040006123A1

文献信息

• Indole derivatives as interleukin -4 gene expression inhibitors
  申请人：——

  公开号：US20040010029A1

  公开（公告）日：2004-01-15

  This invention discloses and claims a new class of indole derivatives for use in treating allergy, asthma, rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial, rhinovirus or respiratory syncytial virus (RSV) infections. It has now been found that the compounds of this invention are capable of modulating T helper (Th) cells, Th1/Th2, and thereby capable of inhibiting the transcription of interleukin-4 (IL-4) message, IL-4 release or IL-4 production.

  这项发明揭示并声明了一类新的吲哚衍生物，用于治疗过敏、哮喘、鼻炎、皮炎、B细胞淋巴瘤、肿瘤以及与细菌、鼻病毒或呼吸道合胞病毒（RSV）感染相关的疾病。现在已经发现，该发明的化合物能够调节T辅助细胞（Th）细胞、Th1 / Th2，从而能够抑制白细胞介素-4（IL-4）信息的转录、IL-4释放或IL-4的产生。
• Interleukin-4 gene expression inhibitors
  申请人：——

  公开号：US20040006123A1

  公开（公告）日：2004-01-08

  This invention discloses and claims a class of indole and benzo(b)thiophene derivatives for use in treating allergy, asthma, rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial, rhinovirus or respiratory syncytial virus (RSV) infections. The compounds of this invention are defined by the Formula (I): 1 wherein X, Y, Z, R 1 , R 2 and R 3 are as defined in the specification; or a pharmaceutically acceptable salt thereof. In preferred embodiments of this invention it is also disclosed and claimed that the compounds of this invention are capable of modulating T helper (Th) cells, Th1/Th2, and thereby capable of inhibiting the transcription of interleukin-4 (IL-4) message, IL-4 release or IL-4 production.

  本发明揭示和声明了一类吲哚和苯并(b)噻吩衍生物，用于治疗过敏、哮喘、鼻炎、皮炎、B细胞淋巴瘤、肿瘤以及与细菌、鼻病毒或呼吸道合胞病毒(RSV)感染相关的疾病。本发明的化合物由式(I)定义：其中X、Y、Z、R1、R2和R3如规范中所定义；或其药学上可接受的盐。在本发明的优选实施方式中，还揭示和声明本发明的化合物能够调节T辅助细胞(Th)、Th1/Th2，并能够抑制白细胞介素-4(IL-4)信息的转录，IL-4的释放或IL-4的产生。
• Indole derivatives as interleukin-4 gene expression inhibitors
  申请人：Aventis Pharmaceuticals Inc.

  公开号：US07169925B2

  公开（公告）日：2007-01-30

  This invention discloses and claims a new class of indole derivatives for use in treating allergy, asthma, rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial, rhinovirus or respiratory syncytial virus (RSV) infections. It has now been found that the compounds of this invention are capable of modulating T helper (Th) cells, Th1/Th2, and thereby capable of inhibiting the transcription of interleukin-4 (IL-4) message, IL-4 release or IL-4 production.

  本发明揭示和声明了一类新的吲哚衍生物，用于治疗过敏、哮喘、鼻炎、皮炎、B细胞淋巴瘤、肿瘤以及与细菌、鼻病毒或呼吸道合胞病毒（RSV）感染相关的疾病。现已发现，本发明的化合物能够调节T辅助细胞（Th）细胞、Th1/Th2细胞，并因此能够抑制白细胞介素-4（IL-4）信息的转录、IL-4的释放或IL-4的产生。
• INTERLEUKIN-4 GENE EXPRESSION INHIBITORS
  申请人：ALKAN Sefik S.

  公开号：US20080132481A1

  公开（公告）日：2008-06-05

  This invention discloses and claims a class of indole and benzo(b)thiophene derivatives for use in treating allergy, asthma, rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial, rhinovirus or respiratory syncytial virus (RSV) infections. The compounds of this invention are defined by the Formula (I): wherein X, Y, Z, R 1 , R 2 and R 3 are as defined in the specification; or a pharmaceutically acceptable salt thereof. In preferred embodiments of this invention it is also disclosed and claimed that the compounds of this invention are capable of modulating T helper (Th) cells, Th1/Th2, and thereby capable of inhibiting the transcription of interleukin-4 (IL-4) message, IL-4 release or IL-4 production.

  本发明揭示和声明了一类用于治疗过敏、哮喘、鼻炎、皮炎、B细胞淋巴瘤、肿瘤以及与细菌、鼻病毒或呼吸道合胞病毒（RSV）感染相关的疾病的吲哚和苯并(b)噻吩衍生物。本发明的化合物由公式（I）定义：其中X、Y、Z、R1、R2和R3如规范中所定义；或其药学上可接受的盐。在本发明的优选实施例中，还揭示和声明本发明的化合物能够调节T辅助（Th）细胞，Th1 / Th2，并能够抑制白细胞介素-4（IL-4）信息的转录、IL-4的释放或IL-4的产生。
• 3-substituted amino-1H-indole-2-carboxylic acid and 3-substituted amino-benzo[B]thiophene-2carboxylic acid derivatives as interleukin-4 gene expression inhibitors
  申请人：Aventis Pharmaceuticals Inc.

  公开号：EP1834947A2

  公开（公告）日：2007-09-19

  This invention discloses and claims a new class of indole derivatives for use in treating allergy, asthma, rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial, rhinovirus or respiratory syncytial virus (RSV) infections. It has now been found that the compounds of this invention are capable of modulating T helper (Th) cells, Thl/Th2, and thereby capable of inhibiting the transcription of interleukin-4 (IL-4) message, IL-4 release or IL-4 production.

  本发明公开了一类新的吲哚衍生物，用于治疗过敏、哮喘、鼻炎、皮炎、B 细胞淋巴瘤、肿瘤以及与细菌、鼻病毒或呼吸道合胞病毒（RSV）感染有关的疾病。现已发现，本发明的化合物能够调节 T 辅助（Th）细胞 Thl/Th2，从而能够抑制白细胞介素-4（IL-4）信息的转录、IL-4 的释放或 IL-4 的产生。