Benzyl 3-(4-fluorophenyl)prop-2-enoate | 380440-27-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: Benzyl 3-(4-fluorophenyl)prop-2-enoate
• CAS: 380440-27-7
• 化学式: C₁₆H₁₃FO₂
• 分子量: 256.276
• InChiKey: PFQZZZKHXPPABD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Benzyl 3-(4-fluorophenyl)prop-2-enoate 、 4-methyl-N-(pent-4-yn-1-yl)benzenesulfonamide 在 gallium(III) triflate 、 dimethylsulfide gold(I) chloride 作用下， 以 甲苯 为溶剂， 反应 1.5h， 以77.778%的产率得到
  参考文献：
  名称：

  Synthesis of Fused Bicyclic Aminals through Sequential Gold/Lewis Acid Catalysis

  摘要：

  A novel sequential catalysis by combining gold catalysis with early transition metal catalysis was developed. Biologically important bicyclo[4.n.0] aminals were obtained under very mild conditions.

  DOI：

  10.1021/ol400803f

文献信息

• Synthesis of Fused Bicyclic Aminals through Sequential Gold/Lewis Acid Catalysis
  作者：Xianghua Wang、Zhili Yao、Shuli Dong、Fang Wei、Hong Wang、Zhenghu Xu

  DOI：10.1021/ol400803f

  日期：2013.5.3

  A novel sequential catalysis by combining gold catalysis with early transition metal catalysis was developed. Biologically important bicyclo[4.n.0] aminals were obtained under very mild conditions.