ethyl 2-(2-fluorobenzoyl)-6-methylindolizine-7-carboxylate | 1144047-47-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ethyl 2-(2-fluorobenzoyl)-6-methylindolizine-7-carboxylate
• 英文别名: Ethyl 2-(2-fluorobenzoyl)-6-methylindolizine-7-carboxylate
• CAS: 1144047-47-1
• 化学式: C₁₉H₁₆FNO₃
• 分子量: 325.339
• InChiKey: DDNXYBUEEMUKCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  47.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (E)-乙基4-溴-3-甲基-2-丁烯酸酯 、 4-(2-fluorobenzoyl)-1H-pyrrol-2-carboxaldehyde 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以76%的产率得到ethyl 2-(2-fluorobenzoyl)-6-methylindolizine-7-carboxylate
  参考文献：
  名称：

  A Facile Approach to Indolizines via Tandem Reaction

  摘要：

  Indolizines were synthesized by a novel tandem reaction at rt. The operation was simple and convenient. Various indolizine derivatives were obtained in good yields. The reaction mechanism was also proposed.

  DOI：

  10.3987/com-08-11570

文献信息

• A Facile Approach to Indolizines via Tandem Reaction
  作者：Jianwu Wang、Yan-Qing Ge、Jiong Jia、He Yang、Gui-Long Zhao、Fu-Xu Zhan

  DOI：10.3987/com-08-11570

  日期：——

  Indolizines were synthesized by a novel tandem reaction at rt. The operation was simple and convenient. Various indolizine derivatives were obtained in good yields. The reaction mechanism was also proposed.