7-methoxy-15-hydroxycryptopleurine | 1034977-50-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 7-methoxy-15-hydroxycryptopleurine
• 英文别名: 2,3,6,7-tetramethoxy-11,12,13,14,14a,15-hexahydro-9H-phenanthro[9,10-b]quinolizin-15-ol
• CAS: 1034977-50-8
• 化学式: C₂₅H₂₉NO₅
• 分子量: 423.509
• InChiKey: QMKFMAIEWFWSKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  60.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  7-methoxy-15-hydroxycryptopleurine 在 三乙基硅烷 作用下， 以 三氟乙酸 为溶剂， 反应 10.0h， 以96%的产率得到7-methoxycryptopleurine
  参考文献：
  名称：

  Highly efficient synthesis of phenanthroquinolizidine alkaloids via Parham-type cycliacylation

  摘要：

  A concise and efficient route involving Parham-type cycliacylation as the key step has been used to synthesize phenanthroquinolizidine alkaloids 1a-c and 2a-c. Among the products, 1b-(S), 1b-(R), 2a-(14S,15S), 2a-(14aR,15R), and 2b were synthesized for the first time. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.12.135
• 作为产物：
  描述：

  1-[(9-bromo-2,3,6,7-tetramethoxyphenanthren-10-yl)methyl]-N,N-diethylpiperidine-2-carboxamide 在 正丁基锂 、 四甲基乙二胺 、 sodium tetrahydroborate 作用下， 以 四氢呋喃 、 正己烷 、 甲醇 为溶剂， 反应 13.0h， 以91%的产率得到7-methoxy-15-hydroxycryptopleurine
  参考文献：
  名称：

  Highly efficient synthesis of phenanthroquinolizidine alkaloids via Parham-type cycliacylation

  摘要：

  A concise and efficient route involving Parham-type cycliacylation as the key step has been used to synthesize phenanthroquinolizidine alkaloids 1a-c and 2a-c. Among the products, 1b-(S), 1b-(R), 2a-(14S,15S), 2a-(14aR,15R), and 2b were synthesized for the first time. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.12.135

文献信息

• PHENANTHROINDOLIZIDINE ANALOGUES
  申请人：Lee Shiow-Ju

  公开号：US20100216773A1

  公开（公告）日：2010-08-26

  Treatment of coronavirus infection with phenanthroindolizidine analogues.

  使用菲南三氮杂环吲哚啉类似物治疗冠状病毒感染。
• US8440649B2
  申请人：——

  公开号：US8440649B2

  公开（公告）日：2013-05-14
• Highly efficient synthesis of phenanthroquinolizidine alkaloids via Parham-type cycliacylation
  作者：Ziwen Wang、Qingmin Wang

  DOI：10.1016/j.tetlet.2009.12.135

  日期：2010.3

  A concise and efficient route involving Parham-type cycliacylation as the key step has been used to synthesize phenanthroquinolizidine alkaloids 1a-c and 2a-c. Among the products, 1b-(S), 1b-(R), 2a-(14S,15S), 2a-(14aR,15R), and 2b were synthesized for the first time. (C) 2010 Elsevier Ltd. All rights reserved.