L-鼠李糖酸 | 6422-34-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 中文名称: L-鼠李糖酸
• 英文名称: rhodeonic acid
• 英文别名: Rhodeonsaeure；D-Galaktomethylonsaeure；D-Fuconsaeure；D-fuconic acid；(2R,3S,4S,5R)-2,3,4,5-tetrahydroxyhexanoic acid
• CAS: 6422-34-0；20246-37-1；26372-13-4；28223-46-3；30516-86-0；67337-08-0；30923-13-8
• 化学式: C₆H₁₂O₆
• 分子量: 180.158
• InChiKey: NBFWIISVIFCMDK-MGCNEYSASA-N

物化性质

• 熔点：
  151 °C
• 沸点：
  543.3±50.0 °C(Predicted)
• 密度：
  1.584±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  118
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  L-鼠李糖酸 在 吡啶 作用下， 生成 D-talomethylonic acid
  参考文献：
  名称：

  合成l-古洛甲基和d- Rhamnits nach neuer Methode

  摘要：

  DOI：

  10.1002/hlca.193802101122
• 作为产物：
  描述：

  D-Fucose 在 3,5-二硝基水杨酸 作用下， 反应 0.25h， 生成 L-鼠李糖酸
  参考文献：
  名称：

  Substrate specificity of galactokinase from Streptococcus pneumoniae TIGR4 towards galactose, glucose, and their derivatives

  摘要：

  Galactokinases (GalKs) have attracted significant research attention for their potential applications in the enzymatic synthesis of unique sugar phosphates. The galactokinase (GalKSpe4) cloned from Streptococcus pneumoniae TIGR4 presents a remarkably broad substrate range including 14 diverse natural and unnatural sugars. TLC and MS studies revealed that GalKSpe4 had relaxed activity towards galactose derivatives with modifications on the C-6, 4- or 2-positions. Additionally, GalKSpe4 can also tolerate glucose while glucose derivatives with modifications on the C-6, 4- or 2-positions were unacceptable. More interestingly, GalKSpe4 can phosphorylate L-mannose in moderate yield (43%), while other L-sugars such as L-Gal cannot be recognized by this enzyme. These results are very significant because there is rarely enzyme reported that can phosphorylate such uncommon substrates as L-mannose. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.03.095

文献信息

• Catalytic dehydrogenation of reducing sugars in alkaline solution
  作者：Gert de Wit、Jan J. de Vlieger、Alida C. Kock-van Dalen、Roelf Heus、Rob Laroy、Antonius J. van Hengstum、Antonius P.G. Kieboom、Herman van Bekkum

  DOI：10.1016/s0008-6215(00)86025-5

  日期：1981.5

  Abstract Aldoses in alkaline medium under the catalytic action of platinum or rhodium are converted into aldonic acids with high selectivity and with concomitant evolution of hydrogen gas. The dehydrogenation reaction has been studied for 25 different mono- and di-saccharides, and is generally applicable for reducing sugars. The influence of several reaction variables has been studied, leading to an

  摘要碱性介质中的醛类在铂或铑的催化作用下被高选择性地转化为醛糖酸，并伴随着氢气的逸出。已经针对25种不同的单糖和二糖研究了脱氢反应，该反应通常可用于还原糖。研究了几个反应变量的影响，得出了一个吸附模型，在该模型中，带负电荷的O-1和H-1与催化剂表面的紧密接触均被视为推动氢化物从C-转移的动力。将1的糖加入催化剂中。
• Dually derivatized chitosan nanoparticles and methods of making and using the same for gene transfer in vivo
  申请人：ENGENE, INC.

  公开号：US10456481B2

  公开（公告）日：2019-10-29

  Provided herein is chitosan-derivative nanoparticle comprising chitosan functionalized with a cationic amino acid and a hydrophilic polyol; and methods of making and using same, e.g., for gene delivery in vivo.

  本文提供了壳聚糖衍生物纳米粒子，包括用阳离子氨基酸和亲水多元醇官能化的壳聚糖；以及制造和使用这种纳米粒子的方法，例如用于体内基因递送。
• Votocek; Krauz, Chemische Berichte, 1911, vol. 44, p. 364
  作者：Votocek、Krauz

  DOI：——

  日期：——
• The Configuration of “α”-D-Glucosaccharinic Acid: 2-C-Methyl-D-ribo-pentonic Acid
  作者：John C. Sowden、Donald R. Strobach

  DOI：10.1021/ja01499a059

  日期：1960.7
• Votocek; Valentin, Collection of Czechoslovak Chemical Communications, 1930, vol. 2, p. 36,42
  作者：Votocek、Valentin

  DOI：——

  日期：——