Adenosine, N-benzoyl-

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: Adenosine, N-benzoyl-
• 英文别名: N-[9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]benzamide
• 化学式: C₁₇H₁₇N₅O₅
• 分子量: 371.3
• InChiKey: NZDWTKFDAUOODA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  143
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• CYCLIC DINUCLEOTIDE COMPOUND AND USES THEREOF
  申请人：SHANGHAI JEMINCARE PHARMACEUTICALS CO., LTD.

  公开号：US20210340169A1

  公开（公告）日：2021-11-04

  Provided are a compound of formula (I), an optical isomer thereof, a pharmaceutically acceptable salt thereof, uses of said compound acting as a STING agonist.

  提供的是化合物（I）的化学式，其光学异构体，其药用盐，以及作为STING激动剂的该化合物的用途。
• Pharmaceutical targeting of a mammalian cyclic di-nucleotide signaling pathway
  申请人：Board of Regents, The University of Texas System

  公开号：US10633411B2

  公开（公告）日：2020-04-28

  Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2′3-cGAMP, 2′2-cGAMP, 3′2′-cGAMP and 3′3′-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies, and diagnostics.

  环-GMP-AMP 合酶（cGAS）和环-GMP-AMP（cGAMP），包括 2′3-cGAMP、2′2-cGAMP、3′2′-cGAMP 和 3′3′-GAMP，可用于药物制剂（包括疫苗佐剂）、药物筛选、治疗和诊断。
• PHARMACEUTICAL TARGETING OF A MAMMALIAN CYCLIC DI-NUCLEOTIDE SIGNALING PATHWAY
  申请人：Board of Regents, The University of Texas System

  公开号：US20200140477A1

  公开（公告）日：2020-05-07

  Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2′3-cGAMP, 2′2-cGAMP, 3′2′-cGAMP and 3′3′-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies, and diagnostics.
• CYCLIC DI-NUCLEOTIDE COMPOUNDS AND METHODS OF USE
  申请人：ImmuneSensor Therapeutics, Inc.

  公开号：US20220340613A1

  公开（公告）日：2022-10-27

  Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.