ethyl valeramidate | 75727-33-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl valeramidate
• 英文别名: 4-(ethylcarbamoyl)butanoic Acid；5-(ethylamino)-5-oxopentanoic acid
• CAS: 75727-33-2
• 化学式: C₇H₁₃NO₃
• mdl: MFCD01352944
• 分子量: 159.185
• InChiKey: SSTGFNDNZPNRMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.714
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (+)-(3aS,4R,7aS)-4-hydroxy-4-(m-tolylethynyl)-octahydro-indole-1-carboxylic acid methyl ester 、 ethyl valeramidate 以to yield (3aR,4S,7aR)-methyl 4-(5-(ethylamino)-5-oxopentanoyloxy)-4-(m-tolylethynyl)octahydro-1H-indole-1-carboxylate的产率得到(3aR,4S,7aR)-methyl 4-(5-(ethylamino)-5-oxopentanoyloxy)-4-(m-tolylethynyl)octahydro-1H-indole-1-carboxylate
  参考文献：
  名称：

  4-Tolyl-ethynyl-octahydro-indole-1-ester derivatives

  摘要：

  该发明涉及化合物(I)的公式，其中取代基如规范中所定义；以自由形式或盐形式存在；其制备方法，其用作药物以及包含它们的药物。

  公开号：

  US20130303538A1

文献信息

• [EN] 4-TOLYL-ETHYNYL-OCTAHYDRO-INDOLE-1-ESTER DERIVATIVES<br/>[FR] DÉRIVÉS DE 4-TOLYL-ÉTHYNYL-OCTAHYDRO-INDOLE-1-ESTER
  申请人：NOVARTIS AG

  公开号：WO2012101058A1

  公开（公告）日：2012-08-02

  The invention relates to compounds of the formula (I) in which the substituents are as defined in the specification; in free form or in salt form; to their preparation, to their use as medicament and to medicaments comprising them.

  该发明涉及以下式（I）的化合物，其中取代基如规范中定义；以自由形式或盐形式存在；其制备方法，作为药物的用途以及包含它们的药物。
• [EN] FATTY ACID MODIFIED HUMAN EPIDERMAL GROWTH FACTOR<br/>[FR] FACTEUR DE CROISSANCE ÉPIDERMIQUE HUMAIN MODIFIÉ PAR ACIDE GRAS
  申请人：UNIV SAINT LOUIS

  公开号：WO2019023295A1

  公开（公告）日：2019-01-31

  The disclosure provides for new epidermal growth factor (EGF)-based reagents that have been modified by fatty acid conjugation. Method of using such agents to treatment Short Bowel Sydnrome (SBS) are also described.

  本公开提供了一种新的表皮生长因子（EGF）基础试剂，该试剂已通过脂肪酸共轭修饰。还描述了使用这些试剂治疗短肠综合征（SBS）的方法。
• Arylindenopyridines and related therapeutic and prophylactic methods
  申请人：——

  公开号：US20040082578A1

  公开（公告）日：2004-04-29

  This invention provides novel arylindenopyridines of the formula: 1 and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing Adensine A2a receptors or reducing PDE activity in appropriate cells. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.

  本发明提供了新型的芳基茚莽啶化合物的公式1及其制成的药物组合物，用于治疗通过拮抗腺苷A2a受体或在适当的细胞中减少PDE活性而改善的疾病。本发明还提供了使用该药物组合物的治疗和预防方法。
• 4-tolyl-ethynyl-octahydro-indole-1-ester derivatives
  申请人：Nozulak Joachim

  公开号：US09067881B2

  公开（公告）日：2015-06-30

  The invention relates to compounds of the formula (I) in which the substituents are as defined in the specification; in free form or in salt form; to their preparation, to their use as medicament and to medicaments comprising them.

  该发明涉及公式（I）中取代基的化合物，其中取代基如规范中定义的；以自由形式或盐形式存在；它们的制备，它们作为药物的用途以及包含它们的药物。
• REVERSIBLY THERMOCHROMIC COMPOSITION, AND REVERSIBLY THERMOCHROMIC MICROCAPSULE PIGMENT HAVING SAME ENCLOSED THEREIN
  申请人：The Pilot Ink Co., Ltd

  公开号：EP3608386A1

  公开（公告）日：2020-02-12

  [Problems] The present invention provides a highly marketable reversibly color changeable composition which provides a vivid yellow to orange color during color development, turns colorless during decoloration, and improves light resistance and a reversibly thermochromic microcapsule pigment encapsulating the same. [Solution] Disclosed are a reversibly thermochromic composition including: (a) a specific pyridine derivative as an electron-donating color-developing organic compound; (b) an electron-accepting compound; and (c) a reaction medium which reversibly induces an electron transfer reaction between the component (a) and the component (b) in a specific temperature range, and a reversibly thermochromic microcapsule pigment encapsulating the same.

  问题 本发明提供了一种高度市场化的可逆变色组合物，该组合物在显色过程中提供鲜艳的黄色至橙色，在脱色过程中变成无色，并提高了耐光性，还提供了封装该组合物的可逆热变色微胶囊颜料。 [解决方案］ 本发明公开了一种可逆热致变色组合物，包括：（a）作为电子捐赠显色有机化合物的特定吡啶衍生物；（b）电子接受化合物；和（c）在特定温度范围内可逆地诱导组分（a）和组分（b）之间发生电子转移反应的反应介质，以及封装该组合物的可逆热致变色微胶囊颜料。