1,1-dimethylethyl (3,5-diethyl-1H-pyrazol-4-yl)acetate | 960061-49-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1,1-dimethylethyl (3,5-diethyl-1H-pyrazol-4-yl)acetate
• 英文别名: (3,5-diethyl-1H-pyrazol-4-yl)-acetic acid tert-butyl ester；tert-butyl 2-(3,5-diethyl-1H-pyrazol-4-yl)acetate
• CAS: 960061-49-8
• 化学式: C₁₃H₂₂N₂O₂
• 分子量: 238.33
• InChiKey: RGMJDKLWIULTDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  55
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,1-dimethylethyl (3,5-diethyl-1H-pyrazol-4-yl)acetate 在 trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II) 水 、 potassium carbonate 、 N,N-二异丙基乙胺 作用下， 以 1,4-二氧六环 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.33h， 生成 4-(4-tert-butoxycarbonylmethyl-3,5-diethyl-pyrazol-1-ylmethyl)-3-fluoro-benzoic acid
  参考文献：
  名称：

  [EN] PYRAZOLE COMPOUNDS AS CRTH2 ANTAGONISTS
  [FR] COMPOSÉS PYRAZOLE COMME ANTAGONISTES DU CRTH2

  摘要：

  本发明涉及具有CRTH2活性的式（I）的吡唑化合物及其药学上可接受的盐，其中W、L1、L2、X、L3、Y、R1和R2如规范和索赔中定义，其用作药物和含有该化合物或与一个或多个活性物质的组合物的药物配方。

  公开号：

  WO2011092140A1
• 作为产物：
  描述：

  4,6-壬烷二酮 在 caesium carbonate 、 肼 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 33.0h， 生成 1,1-dimethylethyl (3,5-diethyl-1H-pyrazol-4-yl)acetate
  参考文献：
  名称：

  Use of libraries to access new chemical space: Applications to CRTH2

  摘要：

  The generation of novel CRTH2 ligands in heavily congested chemical space, by de novo design of libraries is disclosed. Novel (1719) compounds across seven libraries were synthesised. More than 100 of these compounds showed binding potency <3 mu M against CRTH2, with the most potent being 247 nM. These libraries produced novel series and demonstrated that this approach is a viable one. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.04.041

文献信息

• [EN] PYRAZOLE COMPOUNDS AS CRTH2 ANTAGONISTS<br/>[FR] COMPOSÉS PYRAZOLES COMME ANTAGONISTES DU CRTH2
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2012130633A1

  公开（公告）日：2012-10-04

  The present invention relates to pyrazole compounds of formula (I) and pharmaceutically acceptable salts thereof having CRTH2 antagonistic activity, wherein L, Y1, Y2, Y3, Y4, Y5, Z, R1, R2, R3 and n have one of the meanings as indicated in the specification and claims, to their use as medicaments, to pharmaceutical compositions containing said compounds and to pharmaceutical compositions containing said compounds in combination with one or more active substances.

  本发明涉及具有CRTH2拮抗活性的式(I)的吡唑化合物及其药学上可接受的盐，其中L、Y1、Y2、Y3、Y4、Y5、Z、R1、R2、R3和n具有规范和索赔中指示的含义之一，以及它们作为药物的用途，含有所述化合物的药物组合物，以及含有所述化合物与一个或多个活性物质的药物组合物。
• PYRAZOLE COMPOUNDS AS CRTH2 ANTAGONISTS
  申请人：OOST Thorsten

  公开号：US20120028938A1

  公开（公告）日：2012-02-02

  The present invention relates to pyrazole compounds of formula (I) and pharmaceutically acceptable salts thereof having CRTH2-activity, wherein W, L 1 , L 2 , X, L 3 , Y, R 1 and R 2 are as defined in the specification and claims, to their use as medicaments and to pharmaceutical formulations, containing said compounds or containing a combination of said compounds with one or more active substances.

  本发明涉及具有CRTH2活性的式(I)的吡唑化合物及其药学上可接受的盐，其中W、L1、L2、X、L3、Y、R1和R2如规范和索赔中所定义，以及它们作为药物的用途和包含该化合物或包含该化合物与一种或多种活性物质的组合物的制药配方。
• Pyrazole compounds as CRTH2 antagonists
  申请人：Oost Thorsten

  公开号：US08791272B2

  公开（公告）日：2014-07-29

  The present invention relates to pyrazole compounds of formula (I) and pharmaceutically acceptable salts thereof having CRTH2-activity, wherein W, L1, L2, X, L3, Y, R1 and R2 are as defined in the specification and claims, to their use as medicaments and to pharmaceutical formulations, containing said compounds or containing a combination of said compounds with one or more active substances.

  本发明涉及式（I）的吡唑化合物及其药学上可接受的盐，具有CRTH2活性，其中W、L1、L2、X、L3、Y、R1和R2如规范和要求所定义，以及它们作为药物的用途和含有该化合物或含有该化合物与一种或多种活性物质的组合物的制药配方。
• N-(Phenylmethyl)-2-(1H-Pyrazol-4-yl) Acetamide Derivatives as P2X7 Antagonists for the Treatment of Pain, Inflammation and Neurodegeneration
  申请人：Beswick Paul John

  公开号：US20090149524A1

  公开（公告）日：2009-06-11

  The present invention relates to novel pyrazole derivatives of formula (I) which bind to the P2X7 receptor and are capable of interfering with the effects of ATP at the P2X7 receptor: and the use of such compounds or pharmaceutical compositions thereof in the treatment of disorders mediated by the P2X7 receptor, for example pain, inflammation and neurodegeneration.

  本发明涉及一种新的嘧唑衍生物，其化学式为（I），该衍生物与P2X7受体结合，能够干扰ATP在P2X7受体上的作用：以及在治疗由P2X7受体介导的疾病，例如疼痛、炎症和神经退行性方面，使用此类化合物或其制剂的药物组合物。
• WO2007/141267
  申请人：——

  公开号：——

  公开（公告）日：——