N-(2-acetyl-4,5-dichlorophenyl)-2-[diethoxy(oxido)phosphaniumyl]propanamide | 1038743-78-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-(2-acetyl-4,5-dichlorophenyl)-2-[diethoxy(oxido)phosphaniumyl]propanamide
• CAS: 1038743-78-0
• 化学式: C₁₅H₂₀Cl₂NO₅P
• 分子量: 396.207
• InChiKey: BZTNOVNEPOFNSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  87.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-(2-acetyl-4,5-dichlorophenyl)-2-[diethoxy(oxido)phosphaniumyl]propanamide 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 lithium chloride 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以86%的产率得到6,7-dichloro-3,4-dimethyl-1H-quinolin-2-one
  参考文献：
  名称：

  A facile Horner–Wadsworth–Emmons route to 2-quinolones

  摘要：

  2-Quinolones are prepared from o-aminophenylketones by N-acylation with phosphonoalkanoylchlorides, followed by an intramolecular Horner-Wadsworth-Emmons olefination. The transformation proceeds under mild conditions, is generally applicable, gives good yields and can be performed either in two steps or as a one-pot reaction. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.04.088
• 作为产物：
  描述：

  diethyl (1-chloro-1-oxopropan-2-yl)phosphonate 、 乙酮,1-(2-氨基-4,5-二氯苯基)- 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 lithium chloride 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以86%的产率得到N-(2-acetyl-4,5-dichlorophenyl)-2-[diethoxy(oxido)phosphaniumyl]propanamide
  参考文献：
  名称：

  A facile Horner–Wadsworth–Emmons route to 2-quinolones

  摘要：

  2-Quinolones are prepared from o-aminophenylketones by N-acylation with phosphonoalkanoylchlorides, followed by an intramolecular Horner-Wadsworth-Emmons olefination. The transformation proceeds under mild conditions, is generally applicable, gives good yields and can be performed either in two steps or as a one-pot reaction. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.04.088

文献信息

• A facile Horner–Wadsworth–Emmons route to 2-quinolones
  作者：Jens-Uwe Peters、Tony Capuano、Silja Weber、Stéphane Kritter、Matthias Sägesser

  DOI：10.1016/j.tetlet.2008.04.088

  日期：2008.6

  2-Quinolones are prepared from o-aminophenylketones by N-acylation with phosphonoalkanoylchlorides, followed by an intramolecular Horner-Wadsworth-Emmons olefination. The transformation proceeds under mild conditions, is generally applicable, gives good yields and can be performed either in two steps or as a one-pot reaction. (C) 2008 Elsevier Ltd. All rights reserved.