quercetin 5,7,3',4'-tetramethyl ether-3-acetate | 7678-40-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: quercetin 5,7,3',4'-tetramethyl ether-3-acetate
• 英文别名: 3-Acetoxy-3',4',5,7-tetramethoxy-2-flaven-4-on；3-Acetoxy-3,4',5,7-tetramethoxy-flavon；3-acetoxy-2-(3,4-dimethoxy-phenyl)-5,7-dimethoxy-chromen-4-one；3-Acetoxy-2-(3,4-dimethoxy-phenyl)-5,7-dimethoxy-chromen-4-on；3-acetoxy-3',4',5,7-tetramethoxy-flavone；[2-(3,4-Dimethoxyphenyl)-5,7-dimethoxy-4-oxochromen-3-yl] acetate
• CAS: 7678-40-2
• 化学式: C₂₁H₂₀O₈
• 分子量: 400.385
• InChiKey: KXZOYWOWMGPBAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  89.5
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  3-羟基-3,4,5,7-四甲氧基黄酮 、 乙酸酐 在 吡啶 作用下， 生成 quercetin 5,7,3',4'-tetramethyl ether-3-acetate
  参考文献：
  名称：

  Antiproliferative Activities of Citrus Flavonoids against Six Human Cancer Cell Lines

  摘要：

  Citrus fruits contain high concentrations of several classes of phenols, including numerous hydroxycinnamates, flavonoid glycosides, and polymethoxylated flavones. The latter group of compounds occurs without glycosidic linkages and has been shown to inhibit the proliferation of a number of cancer cell lines. This antiproliferative property was further demonstrated against additional human cancer cell lines, and the anti proliferative actions of a series of synthetic methoxylated flavones were also studied. Similar to the naturally occurring compounds, the synthetic compounds exhibited strong antiproliferative activities. In many cases the IC50 values occurred below 10 mum. Other hydroxylated flavone and flavanone aglycons also exhibited antiproliferative activities against the cancer cell lines, with the flavones showing greater activities than the flavanones. Glycosylation of these compounds removed their activity. The strong antiproliferative activities of the polymethoxylated flavones suggest that they may have use as anticancer agents in humans.

  DOI：

  10.1021/jf020121d

文献信息

• Compositions and methods of treating, reducing and preventing cardiovascular diseases and disorders with polymethoxyflavones
  申请人：——

  公开号：US20040214882A1

  公开（公告）日：2004-10-28

  Compositions and methods for the treatment, reduction and/or prevention of cardiovascular diseases and disorders are described. Individuals at high risk for developing or having cardiovascular disease or disorder may be treated with an effective dose of a polymethoxyflavone including limocitrin derivatives, quercetin derivatives, naturally occurring polymethoxyflavones, tocotrienols, and mixtures of these compounds.

  本文描述了治疗、减少和/或预防心血管疾病和障碍的组合物和方法。高风险患有或可能发展心血管疾病或障碍的个体，可以接受有效剂量的多甲氧黄酮，包括柠檬黄素衍生物、槲皮素衍生物、天然多甲氧黄酮、生育三烯酚和这些化合物的混合物。
• METHODS OF TREATING LIVER DISEASE
  申请人：The J. David Gladstone Institutes

  公开号：EP3025727A1

  公开（公告）日：2016-06-01

  The present invention provides methods of treating liver steatosis, liver fibrosis and hepatitis C virus (HCV) infection; methods described include methods of reducing the incidence of complications associated with HCV and cirrhosis of the liver; and methods of reducing viral load, or reducing the time to viral clearance, or reducing morbidity or mortality in the clinical outcomes, in patients suffering from HCV infection.

  本发明提供了治疗肝脏脂肪变性、肝纤维化和丙型肝炎病毒（HCV）感染的方法；所述方法包括降低HCV和肝硬化相关并发症发病率的方法；以及降低HCV感染患者病毒载量、或缩短病毒清除时间、或降低临床结果中发病率或死亡率的方法。
• Soft gel capsules containing polymethoxylated flavones and palm oil tocotrienols
  申请人：Udell G. Ronald

  公开号：US20050249803A1

  公开（公告）日：2005-11-10

  The present invention is directed to soft gel compositions, methods of delivery and packaged nutraceuticals of the soft gel compositions that include at least one polymethoxylated flavone and, optionally, at least one tocotrienol.

  本发明涉及软凝胶组合物、给药方法和软凝胶组合物的包装营养保健品，这些软凝胶组合物包括至少一种聚甲氧基化黄酮和可选的至少一种生育三烯酚。
• Herzig, Monatshefte fur Chemie, 1912, vol. 33, p. 697
  作者：Herzig

  DOI：——

  日期：——
• COMPOSITIONS AND METHODS OF TREATING, REDUCING, AND PREVENTING CARDIOVASCULAR DISEASES AND DISORDERS WITH POLYMETHOXYFLAVONES
  申请人：KGK Synergie

  公开号：EP1278417A1

  公开（公告）日：2003-01-29