2-((tert-Butoxycarbonyl)amino)-3-(quinolin-4-yl)propanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-((tert-Butoxycarbonyl)amino)-3-(quinolin-4-yl)propanoic acid
• 英文别名: 2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-quinolin-4-ylpropanoic acid
• 化学式: C₁₇H₂₀N₂O₄
• 分子量: 316.35
• InChiKey: PYIMRQWQFOYRSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  88.5
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] INHIBITORS OF DIPEPTIDYL PEPTIDASE IV<br/>[FR] INHIBITEURS DE LA DIPEPTIDYL-PEPTIDASE IV
  申请人：ASTRAZENECA AB

  公开号：WO2005040095A1

  公开（公告）日：2005-05-06

  The invention relates to compounds of the formula (I) or pharmaceutically-acceptable salts thereof wherein Ar, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 have any of the meanings defined in the description, which possess dipeptidyl peptidase IV (DPP-IV) inhibitory activity and accordingly have value in the treatment of disease states associated with DPP-IV activity, such as diabetes mellitus. Processes for the preparation of said compounds, intermediates in said processes, pharmaceutical compositions containing said compounds or salts, and the use of said compounds or salts are also described.

  该发明涉及式（I）的化合物或其药学上可接受的盐，其中Ar，R1，R2，R3，R4，R5，R6，R7和R8具有描述中定义的任何含义，这些化合物具有二肽基肽酶IV（DPP-IV）抑制活性，因此在治疗与DPP-IV活性相关的疾病状态，如糖尿病等方面具有价值。还描述了制备该化合物的方法，该方法中间体，含有该化合物或其盐的药物组合物以及使用该化合物或其盐的用途。
• Compounds That Inhibit Replication Of Human Immunodeficiency Virus
  申请人：Balzarini Maria Rene Jan

  公开号：US20080076824A1

  公开（公告）日：2008-03-27

  The present invention relates to the discovery of a novel class of compounds that inhibit the replication of human immunodeficiency virus (HIV) and approaches to identify these compounds. More specifically, it has been found that enzymatically prepared alpha-hydroxyglycinamide and synthetically prepared alpha-hydroxyglycinamide inhibit the replication of HIV in human serum. Embodiments include methods to identify modified glycinamide compounds that inhibit HUV, methods to isolate and synthesize modified glycinamide compounds, and therapeutic compositions comprising these compounds.

  本发明涉及一种新型化合物类别的发现，该类化合物能够抑制人类免疫缺陷病毒（HIV）的复制，并提供了鉴定这些化合物的方法。具体来说，发现经酶法制备的α-羟基甘氨酰胺和人工合成的α-羟基甘氨酰胺能够抑制HIV在人血清中的复制。实施例包括鉴定抑制HUV的改性甘氨酰胺化合物的方法，分离和合成改性甘氨酰胺化合物的方法，以及包含这些化合物的治疗组合物。