5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl acetic acid | 496061-12-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl acetic acid
• 英文别名: 2-(5-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid；2-[5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid
• CAS: 496061-12-2
• 化学式: C₂₃H₂₃NO₄
• 分子量: 377.44
• InChiKey: LFIBJUGNWDZWLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  72.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl acetic acid 生成 (S)-2-(5-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid 、
  参考文献：
  名称：

  Indanylacetic acids as PPAR-δ activator insulin sensitizers

  摘要：

  A series of indane acetic acid derivatives were prepared which show a spectrum of activity as insulin sensitizers and PPAR-ot and PPAR-delta ligands. In vivo data are presented for insulin sensitizers with selectivity for PPAR-delta over PPAR-Oc. (c) 2007 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2007.03.057
• 作为产物：
  描述：

  2-(5-甲基-2-苯基-1,3-恶唑-4-基)-1-乙醇 在 lithium hydroxide 、 三苯基膦 、 1,1'-azodicarbonyl-dipiperidine 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl acetic acid
  参考文献：
  名称：

  Indanylacetic acids as PPAR-δ activator insulin sensitizers

  摘要：

  A series of indane acetic acid derivatives were prepared which show a spectrum of activity as insulin sensitizers and PPAR-ot and PPAR-delta ligands. In vivo data are presented for insulin sensitizers with selectivity for PPAR-delta over PPAR-Oc. (c) 2007 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2007.03.057

文献信息

• Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
  申请人：——

  公开号：US20030216391A1

  公开（公告）日：2003-11-20

  This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.

  这项发明涉及新颖的茚基乙酸衍生物，可用于治疗糖尿病、肥胖症、高脂血症和动脉粥样硬化等疾病。该发明还涉及用于制备茚基乙酸衍生物的中间体以及制备方法。
• [EN] INDANE ACETIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS, INTERMEDIATES, AND METHOD OF PREPARATION<br/>[FR] DERIVES D'ACIDE ACETIQUE D'INDANE ET LEUR UTILISATION EN TANT QU'AGENTS THERAPEUTIQUES, PRODUITS INTERMEDIAIRES, ET LEUR METHODE DE PREPARATION
  申请人：BAYER AG

  公开号：WO2003011842A1

  公开（公告）日：2003-02-13

  This invention relates to novel indane acetic acid derivatives of formula (I) which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates of formula (II) a nd (III) of indane acetic derivatives and to methods of prepa ration.

  本发明涉及一种新型吲哚乙酸衍生物的化合物，其化学式为(I)，可用于治疗糖尿病、肥胖症、高脂血症和动脉粥样硬化等疾病。本发明还涉及吲哚乙酸衍生物的中间体化合物，其化学式为(II)和(III)，以及制备方法。
• INDANE ACETIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS, INTERMEDIATES, AND METHOD OF PREPARATION
  申请人：Bayer Corporation

  公开号：EP1414809A1

  公开（公告）日：2004-05-06
• US6828335B2
  申请人：——

  公开号：US6828335B2

  公开（公告）日：2004-12-07
• [EN] METHODS OF TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES BASED ON APOE4 GENOTYPE<br/>[FR] MÉTHODES DE TRAITEMENT OU DE PRÉVENTION D'UN TROUBLE COGNITIF À L'AIDE DE DÉRIVÉS D'ACIDE INDANE ACÉTIQUE BASÉES SUR LE GÉNOTYPE APOE4
  申请人：T3D THERAPEUTICS INC

  公开号：WO2018102358A1

  公开（公告）日：2018-06-07

  The present invention provides indane acetic acid and their derivatives and methods for the treating and/or preventing of cognitive disorders based on the ApoE4 genotype of human subjects.