N,N'-二烯丙基-L,3-丙二胺二盐酸盐 | 205041-15-2

• 物质功能分类: 有机原料 - 氨基化合物 - 无环单胺、多胺及其衍生物和盐
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N,N'-二烯丙基-L,3-丙二胺二盐酸盐
• 英文名称: N,N'-Di-2-propenyl-1,3-propanediamine dihydrochloride
• 英文别名: N,N'-bis(prop-2-enyl)propane-1,3-diamine;dihydrochloride
• CAS: 205041-15-2
• 化学式: C9H20Cl2N2
• 分子量: 227.17
• InChiKey: FIOHNBDWNRXDFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.77
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  24.1
• 氢给体数：
  4
• 氢受体数：
  2

文献信息

• CROSSLINKED POLYALLYLAMINE OR ACID ADDITION SALT THEREOF, AND USE THEREOF FOR MEDICAL PURPOSES
  申请人：Inoue Atsushi

  公开号：US20100189679A1

  公开（公告）日：2010-07-29

  A cross-linked polyallylamine or an acid addition salt thereof has both high phosphate adsorption capability and low degree of swelling, and a medical use thereof. The cross-linked polyallylamine or an acid addition salt thereof is obtained by copolymerization of allylammonium dihydrogen phosphate with an acid addition salt of N,N′-diallyl-1,3-diaminopropane in an amount of 5 to 25 mol % with respect to the amount of the allylammonium dihydrogen phosphate, the cross-linked polyallylamine or an acid addition salt thereof having a phosphate adsorption capacity of 2.7 to 5.0 mmol/g; and a degree of swelling of 2.0 to 5.0. The cross-linked polyallylamine or an acid addition salt thereof is useful as a therapeutic or prophylactic agent for hyperphosphatemia.

  一种交联的聚合物聚合物或其酸加成盐具有高磷酸盐吸附能力和低肿胀度，并且具有医学用途。该交联的聚合物聚合物或其酸加成盐是通过将磷酸氢铵丙烯酰胺与N，N'-二烯丙基-1，3-二氨基丙烷的酸加成盐共聚合而得到的，其与磷酸氢铵丙烯酰胺的量比为5至25摩尔％，所述交联的聚合物聚合物或其酸加成盐具有2.7至5.0毫摩尔/克的磷酸盐吸附能力和2.0至5.0的肿胀度。该交联的聚合物聚合物或其酸加成盐可用作治疗或预防高磷血症的药物。
• COMPOSITIONS FOR TREATING ACID-BASE DISORDERS
  申请人：Tricida Inc.

  公开号：EP3831395A1

  公开（公告）日：2021-06-09

  Pharmaceutical compositions for and methods of treating an animal, including a human, and methods of preparing such compositions. The pharmaceutical compositions contain nonabsorbable compositions and may be used, for example, to treat diseases or other metabolic conditions in which removal of protons, the conjugate base of a strong acid and/or a strong acid from the gastrointestinal tract would provide physiological benefits such as normalizing serum bicarbonate concentrations and the blood pH in an animal, including a human.

  用于治疗动物（包括人）的药物组合物和方法，以及制备这种组合物的方法。这些药物组合物含有不可吸收的成分，可用于治疗疾病或其他代谢状况，在这些疾病或代谢状况中，从胃肠道中清除质子、强酸的共轭碱和/或强酸将带来生理益处，例如使动物（包括人类）的血清碳酸氢盐浓度和血液 pH 值正常化。
• CROSSLINKED POLY(ALLYLAMINE) POLYMER PHARMACEUTICAL COMPOSITIONS
  申请人：Tricida Inc.

  公开号：EP4053179A1

  公开（公告）日：2022-09-07

  Pharmaceutical compositions for and methods of treating an animal, including a human, and methods of preparing such compositions. The pharmaceutical compositions contain crosslinked amine polymers and may be used, for example, to treat diseases or other metabolic conditions in which removal of a target species from the gastrointestinal tract would provide physiological benefits.

  用于治疗动物（包括人类）的药物组合物和方法，以及制备这种组合物的方法。这些药物组合物含有交联胺聚合物，可用于治疗疾病或其他代谢疾病，在这些疾病或代谢疾病中，从胃肠道中清除目标物种可带来生理益处。
• METHOD OF TREATING ACID-BASE DISORDERS
  申请人：Tricida, Inc.

  公开号：EP3703707A1

  公开（公告）日：2020-09-09
• COMPOSITIONS FOR AND METHOD OF TREATING ACID-BASE DISORDERS
  申请人：Tricida Inc.

  公开号：EP3703706A1

  公开（公告）日：2020-09-09