3,3,6,6-tetramethyl-9-(4-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroacridine-1,8-dione dioxime | 401633-11-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3,3,6,6-tetramethyl-9-(4-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroacridine-1,8-dione dioxime
• 英文别名: N-[8-hydroxyimino-9-(4-methoxyphenyl)-3,3,6,6-tetramethyl-2,4,5,7-tetrahydroacridin-1-ylidene]hydroxylamine
• CAS: 401633-11-2
• 化学式: C₂₄H₂₉N₃O₃
• 分子量: 407.513
• InChiKey: WZPXFQLZVAITEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  30
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  87.3
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  10-hydroxy-9-(4-methoxyphenyl)-3,3,6,6-tetramethyl-1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione 在 盐酸羟胺 作用下， 以 吡啶 为溶剂， 反应 3.0h， 以81%的产率得到3,3,6,6-tetramethyl-9-(4-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroacridine-1,8-dione dioxime
  参考文献：
  名称：

  Synthesis and transformations of new 1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione derivatives

  摘要：

  Reactions of cyclohexane-1,3-diones with amines and aldehydes led to the formation of 1,21,3,4,5,16,7,8,9, 10-decahydroacridine-1,8-diones containing alkylaryl, aryl, and hydroxy substituents in position 10. Transformations of 10-hydroxy-1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-diones under oxidation with nitrous acid, reduction with zinc powder, as well as on heating in aprotic solvents and acetic, phosphoric, and polyphosphoric acids, were studied. NMR spectra of 1,2,3,4,5,6,7,8,9,10-decaliydroacridine-1,8-diones having different substituents in positions 9 and 10 were analyzed.

  DOI：

  10.1134/s1070428008080198

文献信息

• Synthesis and transformations of new 1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione derivatives
  作者：A. N. Pyrko

  DOI：10.1134/s1070428008080198

  日期：2008.8

  Reactions of cyclohexane-1,3-diones with amines and aldehydes led to the formation of 1,21,3,4,5,16,7,8,9, 10-decahydroacridine-1,8-diones containing alkylaryl, aryl, and hydroxy substituents in position 10. Transformations of 10-hydroxy-1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-diones under oxidation with nitrous acid, reduction with zinc powder, as well as on heating in aprotic solvents and acetic, phosphoric, and polyphosphoric acids, were studied. NMR spectra of 1,2,3,4,5,6,7,8,9,10-decaliydroacridine-1,8-diones having different substituents in positions 9 and 10 were analyzed.