3-ethylsulfanyl-2-hydroxy-propionaldehyde diethylacetal | 98958-03-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-ethylsulfanyl-2-hydroxy-propionaldehyde diethylacetal
• 英文别名: 1,1-Diaethoxy-3-aethylmercapto-propan-2-ol；3-Aethylmercapto-2-hydroxy-propionaldehyd-diaethylacetal；1,1-Diethoxy-3-(ethylsulfanyl)-2-propanol；1,1-diethoxy-3-ethylsulfanylpropan-2-ol
• CAS: 98958-03-3
• 化学式: C₉H₂₀O₃S
• 分子量: 208.322
• InChiKey: QRLUSFRIZFDHDF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  64
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-ethylsulfanyl-2-hydroxy-propionaldehyde diethylacetal 在 1,4-二氧六环 、 硫酸 作用下， 生成 3-ethylsulfanyl-2-hydroxy-propionaldehyde
  参考文献：
  名称：

  The Preparation of 2-Alkylbutadienes¹

  摘要：

  DOI：

  10.1021/ja01185a006
• 作为产物：
  描述：

  环氧丙烯醛缩二乙醇 、 乙硫醇 在 氢氧化钾 作用下， 生成 3-ethylsulfanyl-2-hydroxy-propionaldehyde diethylacetal
  参考文献：
  名称：

  Some Reactions of Glycidaldehyde Diethylacetal

  摘要：

  DOI：

  10.1021/ja01564a045

文献信息

• Preparation of optically pure L-2-hydroxyaldehydes with yeast transketolase
  作者：Franz Effenberger、Volker Null、Thomas Ziegler

  DOI：10.1016/s0040-4039(00)79121-0

  日期：1992.9

  L-2-Hydroxyaldehydes L-3 with a great variety of substituents in 3-position are obtained in good chemical and excellent optical yields by kinetic resolution in the transketolase-catalyzed reaction of racemic 2-hydroxyaldehydes with lithium hydroxypyruvate 4 where only the enantiomer (R)-3 reacts to 5-deoxy-D-xyluloses 5.

  L-2-羟基醛L- 3在3位上有很大的各种取代基以良好的化学和由外消旋2-羟基醛的转酮酶-催化反应动力学拆分良好的光学收率与锂羟基丙酮酸得到4，其中只对映异构体（R）-3与5-脱氧-D-木酮糖5反应。
• SUBSTITUTED AMINOTETRAHYDROTHIOPYRANS AND DERIVATIVES THEREOF AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OF DIABETES
  申请人：Wilkening Robert R.

  公开号：US20120277240A1

  公开（公告）日：2012-11-01

  The present invention is directed to novel substituted aminotetrahydrothiopyrans and derivatives thereof of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

  本发明涉及一种新型的取代氨基四氢硫吡喃及其衍生物，其化学结构式为(I)，这些化合物是二肽基肽酶-IV酶的抑制剂，可用于治疗或预防二肽基肽酶-IV酶参与的疾病，如糖尿病，特别是2型糖尿病。本发明还涉及包含这些化合物的制药组合物，以及这些化合物和组合物在预防或治疗二肽基肽酶-IV酶参与的疾病方面的用途。
• SUBSTITUTED SEVEN-MEMBERED HETEROCYCLIC COMPOUNDS AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OF DIABETES
  申请人：Hicks Jacqueline D.

  公开号：US20130203786A1

  公开（公告）日：2013-08-08

  The present invention is directed to novel amino-substituted seven-membered heterocyclic compounds of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

  本发明涉及结构式(I)的新型氨基取代七元杂环化合物，其是二肽基肽酶IV酶的抑制剂，可用于治疗或预防二肽基肽酶IV酶参与的疾病，如糖尿病，特别是2型糖尿病。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗二肽基肽酶IV酶参与的疾病方面使用这些化合物和组合物。
• US8853212B2
  申请人：——

  公开号：US8853212B2

  公开（公告）日：2014-10-07
• US8980929B2
  申请人：——

  公开号：US8980929B2

  公开（公告）日：2015-03-17