4-Chloro-N-[2-(6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-YL)ethyl]benzene-1-sulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-Chloro-N-[2-(6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-YL)ethyl]benzene-1-sulfonamide
• 英文别名: 4-chloro-N-[2-(6,7-dimethyl-2-oxo-1H-quinolin-3-yl)ethyl]benzenesulfonamide
• 化学式: C₁₉H₁₉ClN₂O₃S
• mdl: MFCD04462972
• 分子量: 390.9
• InChiKey: PZRAWRYIFVJWSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  83.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• IDENTIFICATION OF COMPOUNDS THAT DISPERSE TDP-43 INCLUSIONS
  申请人：AQUINNAH PHARMACEUTICALS, INC.

  公开号：US20170088515A1

  公开（公告）日：2017-03-30

  Herein, compounds and compositions for use in treating diseases relating to inclusion formation and stress granules are described. Methods for screening for modulation of TDP-43 aggregation are also described.
• [EN] IDENTIFICATION OF COMPOUNDS THAT DISPERSE TDP-43 INCLUSIONS<br/>[FR] IDENTIFICATION DE COMPOSÉS QUI DISPERSENT DES INCLUSIONS DE TDP-43
  申请人：WOLOZIN BENJAMIN

  公开号：WO2012162249A1

  公开（公告）日：2012-11-29

  Herein, methods of modulating inclusion formation and stress granules in cells are described. The methods comprise contacting a cell with an inclusion inhibitor. Methods for screening for modulators of TDP-43 aggregation are also described.