(Z)-3-(bromomethyl)-4-ethoxy-1,1-difluorobut-3-en-2-one | 1526933-15-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (Z)-3-(bromomethyl)-4-ethoxy-1,1-difluorobut-3-en-2-one
• CAS: 1526933-15-2
• 化学式: C₇H₉BrF₂O₂
• 分子量: 243.048
• InChiKey: OCBJHDGHGAUUBQ-SNAWJCMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (E)-4-ethoxy-1,1-difluoro-3-methyl-but-3-en-2-one 在 N-溴代丁二酰亚胺(NBS) 、 过氧化苯甲酰 作用下， 以 四氯化碳 为溶剂， 反应 2.0h， 以64%的产率得到(Z)-3-(bromomethyl)-4-ethoxy-1,1-difluorobut-3-en-2-one
  参考文献：
  名称：

  Synthesis and Properties of α-Bromomethyl-Substituted β-Ethoxyvinyl Polyfluoroalkyl Ketones

  摘要：

  An efficient and practical method for the synthesis of -bromomethyl-substituted -alkoxyvinyl polyfluoroalkyl ketones is reported. These highly functionalized -bromomethyl enones easily react with various nucleophiles and binucleophiles affording a wide variety of new functionalized enones and heterocyclic systems that are perspective starting materials for the synthesis of compounds with potentially high biological and pharmacological activity.

  DOI：

  10.1055/s-0033-1339668

文献信息

• Synthesis and Properties of α-Bromomethyl-Substituted β-Ethoxyvinyl Polyfluoroalkyl Ketones
  作者：Igor Gerus、Maksym Bugera、Karen Tarasenko、Valery Kukhar、Gerd-Volker Röschenthaler

  DOI：10.1055/s-0033-1339668

  日期：——

  An efficient and practical method for the synthesis of -bromomethyl-substituted -alkoxyvinyl polyfluoroalkyl ketones is reported. These highly functionalized -bromomethyl enones easily react with various nucleophiles and binucleophiles affording a wide variety of new functionalized enones and heterocyclic systems that are perspective starting materials for the synthesis of compounds with potentially high biological and pharmacological activity.