N-isopropyl-2-phenylquinolin-4-amine | 128924-99-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-isopropyl-2-phenylquinolin-4-amine
• 英文别名: 2-phenyl-N-propan-2-ylquinolin-4-amine
• CAS: 128924-99-2
• 化学式: C₁₈H₁₈N₂
• 分子量: 262.354
• InChiKey: LMTXKFFRXGLJEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  在 盐酸 作用下， 以 水 为溶剂， 反应 0.25h， 以0.216 g的产率得到N-isopropyl-2-phenylquinolin-4-amine
  参考文献：
  名称：

  Modular Three-Component Synthesis of 4-Aminoquinolines via an Imidoylative Sonogashira/Cyclization Cascade

  摘要：

  We developed a one-pot, two-stage synthetic route to substituted 4-aminoquinolines involving an imidoylative Sonogashira coupling followed by acid-mediated cyclization. This three-component reaction affords pharmaceutically valuable 4-aminoquinolines in a one-pot procedure from readily available starting materials. The reaction tolerates various substituents on the arene as well as the use of secondary and even primary isocyanides. Additionally, the wide tolerance for functionalized isocyanides allows for the one-pot synthesis of various substituted chloroquine analogues as well as other medicinally relevant products.

  DOI：

  10.1021/acs.joc.7b02844

文献信息

• An unusual base-mediated cyclization of ketimines derived from 2-(trifluoromethyl)aniline that involves the trifluoromethyl group: an expedient route to 2-arylquinolines
  作者：Lucjan Strekowski、Roman L. Wydra、Marek T. Cegla、Agnieszka Czarny、Donald B. Harden、Steven E. Patterson、Merle A. Battiste、James M. Coxon

  DOI：10.1021/jo00303a001

  日期：1990.8
• STREKOWSKI, LUCJAN;WYDRA, ROMAN L.;CEGLA, MAREK T.;CZARNY, AGNIESZKA;HARD+, J. ORG. CHEM., 55,(1990) N6, C. 4777-4779
  作者：STREKOWSKI, LUCJAN、WYDRA, ROMAN L.、CEGLA, MAREK T.、CZARNY, AGNIESZKA、HARD+

  DOI：——

  日期：——