1-benzyl-3-(4-chlorophenyl)-N'-(3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-1H-pyrazole-5-carbohydrazide | 1197002-29-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-benzyl-3-(4-chlorophenyl)-N'-(3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-1H-pyrazole-5-carbohydrazide
• 英文别名: 2-benzyl-5-(4-chlorophenyl)-N'-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]pyrazole-3-carbohydrazide
• CAS: 1197002-29-1
• 化学式: C₂₃H₂₅ClN₄O₆
• 分子量: 488.928
• InChiKey: UYCWEBZTVJWARI-ZFVIQDPVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  149
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  1-benzyl-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide 、 葡萄糖 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 以90.1%的产率得到1-benzyl-3-(4-chlorophenyl)-N'-(3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-1H-pyrazole-5-carbohydrazide
  参考文献：
  名称：

  Synthesis and discovery of pyrazole-5-carbohydrazide N-glycosides as inducer of autophagy in A549 lung cancer cells

  摘要：

  A series of novel 3-aryl-1-arylmethyl-1H-pyrazole-5-carbohydrazide N-beta-glycoside derivatives was synthesized by the reaction of substituted 1H-pyrazole-5-carbohydrazide with D-sugar and the effects of all the compounds on A549 cell growth were investigated. The results showed that all compounds had inhibitory effects on the growth of A549 lung cancer cells and compound 3d possessed the highest growth inhibitory effect and induced autophagy of A549 lung cancer cells. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.09.004

文献信息

• Synthesis and discovery of pyrazole-5-carbohydrazide N-glycosides as inducer of autophagy in A549 lung cancer cells
  作者：Song Lian、Hua Su、Bao-Xiang Zhao、Wei-Yong Liu、Liang-Wen Zheng、Jun-Ying Miao

  DOI：10.1016/j.bmc.2009.09.004

  日期：2009.10

  A series of novel 3-aryl-1-arylmethyl-1H-pyrazole-5-carbohydrazide N-beta-glycoside derivatives was synthesized by the reaction of substituted 1H-pyrazole-5-carbohydrazide with D-sugar and the effects of all the compounds on A549 cell growth were investigated. The results showed that all compounds had inhibitory effects on the growth of A549 lung cancer cells and compound 3d possessed the highest growth inhibitory effect and induced autophagy of A549 lung cancer cells. (C) 2009 Elsevier Ltd. All rights reserved.