Dibutyl 5-[[2-[[3-[(2-aminoacetyl)amino]-5-[[2-[3,5-bis(butoxycarbonyl)anilino]-2-oxoethyl]carbamoyl]benzoyl]amino]acetyl]amino]benzene-1,3-dicarboxylate | 852355-49-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Dibutyl 5-[[2-[[3-[(2-aminoacetyl)amino]-5-[[2-[3,5-bis(butoxycarbonyl)anilino]-2-oxoethyl]carbamoyl]benzoyl]amino]acetyl]amino]benzene-1,3-dicarboxylate
• CAS: 852355-49-8
• 化学式: C₄₆H₅₈N₆O₁₃
• 分子量: 902.999
• InChiKey: NTDQMLRZSYZFGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  65
• 可旋转键数：
  30
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  277
• 氢给体数：
  6
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  5-(2-((2-oxo-2-phenyl-1λ²-ethyl)amino)acetamido)isophthalic acid 、 Dibutyl 5-[[2-[[3-[(2-aminoacetyl)amino]-5-[[2-[3,5-bis(butoxycarbonyl)anilino]-2-oxoethyl]carbamoyl]benzoyl]amino]acetyl]amino]benzene-1,3-dicarboxylate 在 N-甲基吗啉 、 4-chloro-2,4-dimethoxytriazine 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 以73%的产率得到
  参考文献：
  名称：

  Arylamide Dendrimers with Flexible Linkers via Haloacyl Halide Method

  摘要：

  Soluble arylamide dendrons with flexible linkers, peripheral ester or carboxyl groups (R), and focal amino or halogen functionalities (F) were synthesized from aryl glycineamide (AG) building blocks. The AG blocks were prepared in high yields from trivial starting materials by Fischer's haloacyl halide method, which also could be extended to the dendrimer synthesis itself. The G2 AG dendrons were coupled to a Pd porphyrin core, demonstrating outstanding encapsulation efficiency in aqueous solutions.

  DOI：

  10.1021/ol050341n
• 作为产物：
  描述：

  5-硝基间苯二甲酸二丁酯 在 palladium on activated charcoal 吡啶 、 氨 、 氢气 、 ammonium formate 、 sodium carbonate 、 potassium carbonate 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 23.5h， 生成 Dibutyl 5-[[2-[[3-[(2-aminoacetyl)amino]-5-[[2-[3,5-bis(butoxycarbonyl)anilino]-2-oxoethyl]carbamoyl]benzoyl]amino]acetyl]amino]benzene-1,3-dicarboxylate
  参考文献：
  名称：

  Arylamide Dendrimers with Flexible Linkers via Haloacyl Halide Method

  摘要：

  Soluble arylamide dendrons with flexible linkers, peripheral ester or carboxyl groups (R), and focal amino or halogen functionalities (F) were synthesized from aryl glycineamide (AG) building blocks. The AG blocks were prepared in high yields from trivial starting materials by Fischer's haloacyl halide method, which also could be extended to the dendrimer synthesis itself. The G2 AG dendrons were coupled to a Pd porphyrin core, demonstrating outstanding encapsulation efficiency in aqueous solutions.

  DOI：

  10.1021/ol050341n

文献信息

• IMAGING DENDRIMER NANOPROBES AND USES THEREOF
  申请人：Vinogradov Sergei A.

  公开号：US20110117020A1

  公开（公告）日：2011-05-19

  This invention relates to imaging nanoprobe and methods of use thereof. Specifically, the invention relates to long-lived oxygen-insensitive nanoprobe comprising a lumisescent moeity with a long excited state lifetime, embedded in a dendrimer, wherein said dendrimer is internally cross-linked and has hydrophilic peripheral layer.

  这项发明涉及成像纳米探针及其使用方法。具体而言，该发明涉及一种长寿命的氧不敏感纳米探针，包括一个具有长激发态寿命的发光基团，嵌入在一个树枝状聚合物中，所述树枝状聚合物内部交联，并具有亲水性外周层。
• Arylamide Dendrimers with Flexible Linkers via Haloacyl Halide Method
  作者：Sergei A. Vinogradov

  DOI：10.1021/ol050341n

  日期：2005.4.1

  Soluble arylamide dendrons with flexible linkers, peripheral ester or carboxyl groups (R), and focal amino or halogen functionalities (F) were synthesized from aryl glycineamide (AG) building blocks. The AG blocks were prepared in high yields from trivial starting materials by Fischer's haloacyl halide method, which also could be extended to the dendrimer synthesis itself. The G2 AG dendrons were coupled to a Pd porphyrin core, demonstrating outstanding encapsulation efficiency in aqueous solutions.