5-(2-((2-oxo-2-phenyl-1λ²-ethyl)amino)acetamido)isophthalic acid | 852355-43-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(2-((2-oxo-2-phenyl-1λ²-ethyl)amino)acetamido)isophthalic acid
• 英文别名: 5-(2-(((Benzyloxy)carbonyl)amino)acetamido)isophthalic acid；5-[[2-(phenylmethoxycarbonylamino)acetyl]amino]benzene-1,3-dicarboxylic acid
• CAS: 852355-43-2
• 化学式: C₁₈H₁₆N₂O₇
• 分子量: 372.334
• InChiKey: KYGNKMDWPUNSAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  142
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  5-(2-((2-oxo-2-phenyl-1λ²-ethyl)amino)acetamido)isophthalic acid 在 palladium on activated charcoal N-甲基吗啉 、 2-chloro-4,6-dimethoxytriazine 、 氢气 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  Phosphorescent Oxygen Sensor with Dendritic Protection and Two-Photon Absorbing Antenna

  摘要：

  Imaging oxygen in 3D with submicron spatial resolution can be made possible by combining phosphorescence quenching technique with multiphoton laser scanning microscopy. Because Pt and Pd porphyrin-based phosphorescent dyes, traditionally used as phosphors in biological oxygen measurements, exhibit extremely low two-photon absorption (2PA) cross-sections, we designed a nanosensor for oxygen, in which a 2P absorbing antenna is coupled to a metalloporphyrin core via intramolecular energy transfer (ET) with the purpose of amplifying the 2PA induced phosphorescence of the metalloporphyrin. The central component of the device is a polyfunctionalized Pt porphyrin, whose triplet state emission at ambient temperatures is strong, occurs in the near infrared and is sensitive to O-2. The 2PA chromophores are chosen in such a way that their absorption is maximal in the near infrared (NIR) window of tissue (e.g., 700-900 nm), while their fluorescence is overlapped with the absorption band(s) of the core metalloporphyrin, ensuring an efficient antenna-core resonance ET. The metalloporphyrin-antenna construct is embedded inside the protecting dendritic jacket, which isolates the core from interactions with biological macromolecules, controls diffusion of oxygen and makes the entire sensor water-soluble. Several Pt porphyrin-cournarin based sensors were synthesized and their photophyics studied to evaluate the proposed design.

  DOI：

  10.1021/ja052947c
• 作为产物：
  描述：

  N-苄氧羰基甘氨酸 在 N-甲基吗啉 、 甲醇 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 sodium hydroxide 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 5-(2-((2-oxo-2-phenyl-1λ²-ethyl)amino)acetamido)isophthalic acid
  参考文献：
  名称：

  WO2020093061A5

  摘要：

  公开号：

  WO2020093061A5

文献信息

• [EN] TARGETED NUCLEIC ACID CONJUGATE COMPOSITIONS<br/>[FR] COMPOSITIONS DE CONJUGUÉS D'ACIDES NUCLÉIQUES CIBLÉS
  申请人：PROTIVA BIOTHERAPEUTICS INC

  公开号：WO2017177326A1

  公开（公告）日：2017-10-19

  The invention provides conjugates that comprise a targeting moiety, a nucleic acid, and optional linking groups as well as synthetic intermediates and synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic nucleic acids to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).

  这项发明提供了包括靶向基团、核酸和可选连接基团的共轭物，以及用于制备这些共轭物的合成中间体和合成方法。这些共轭物可用于将治疗性核酸靶向肝脏，并用于治疗包括肝炎（如乙型肝炎和丙型肝炎）在内的肝脏疾病。
• Robust multidentate ligands for diagnosis and anti-viral drugs for influenza and related viruses
  申请人：Swanson Basil I.

  公开号：US20080194801A1

  公开（公告）日：2008-08-14

  Design and synthesis of a novel library of compounds comprising a spacer with an attachment element on one terminus and a recognition element on the other terminus is presented. The library of compounds can be attached to a solid support and used as an integral component of sensors and biosensors or the library of compounds can be used as antiviral drugs or to isolate pathogens from complex mixtures for further analysis.

  提出了一种包含一个具有附件元素的间隔物和另一个端点上的识别元素的新型化合物库的设计和合成。这种化合物库可以连接到固体支持体上，并用作传感器和生物传感器的整体组成部分，或者可以用作抗病毒药物，或者用于从复杂混合物中分离病原体以进行进一步分析。
• [EN] TARGETED COMPOSITIONS<br/>[FR] COMPOSITIONS CIBLÉES
  申请人：ARBUTUS BIOPHARMA CORP

  公开号：WO2018191278A3

  公开（公告）日：2018-11-22
• [EN] METHODS FOR TREATING HEPATITIS B INFECTIONS<br/>[FR] MÉTHODES DE TRAITEMENT DES INFECTIONS DE TYPE HÉPATITE B
  申请人：ARBUTUS BIOPHARMA CORP

  公开号：WO2019051257A3

  公开（公告）日：2020-03-26
• Synthesis of soluble multivalent glycoconjugates that target the Hc region of botulinum neurotoxin A
  作者：Ramesh R. Kale、Colin M. Clancy、Rebecca M. Vermillion、Eric A. Johnson、Suri S. Iyer

  DOI：10.1016/j.bmcl.2007.02.028

  日期：2007.5

  The design, synthesis, and initial inhibitory studies of di- and tetravalent glycoconjugates that target the heavy chain of botulinum neurotoxin A are reported. (C) 2007 Elsevier Ltd. All rights reserved.