ortho-isopropoxy (2'-hydroxypropyl)benzene | 1087396-28-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ortho-isopropoxy (2'-hydroxypropyl)benzene
• 英文别名: 1-(2-Isopropoxyphenyl)propan-2-ol；1-(2-propan-2-yloxyphenyl)propan-2-ol
• CAS: 1087396-28-8
• 化学式: C₁₂H₁₈O₂
• 分子量: 194.274
• InChiKey: OBYFDIBXMYEEBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  ortho-isopropoxy (2'-hydroxypropyl)benzene 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 生成 1-isopropoxy-2-(prop-1-en-1-yl)benzene
  参考文献：
  名称：

  CHELATING CARBENE LIGAND PRECURSORS AND THEIR USE IN THE SYNTHESIS OF METATHESIS CATALYSTS

  摘要：

  揭示了用于制备烯烃转化催化剂的螯合配体前体。所得的催化剂是空气稳定的单体物种，能够高效促进各种转化反应，并可从反应混合物中回收并重复使用。内部烯烃化合物，特别是β-取代苯乙烯，被用作配体前体。与未取代苯乙烯等末端烯烃化合物相比，β-取代苯乙烯更容易、成本更低，并且更稳定，因为它们不太容易自发聚合。揭示了一种无需使用CuCl制备螯合-卡宾转化催化剂的方法。通过用有机酸、矿酸、温和氧化剂甚至水替代CuCl，从而获得高产率的Hoveyda型转化催化剂，从而消除了对CuCl的需求。该发明提供了一种有效的方法，通过在高浓度的配体前体中与适当的钌配合物反应，然后从有机溶剂中结晶，制备螯合-卡宾转化催化剂。

  公开号：

  US20030166955A1
• 作为产物：
  描述：

  ortho-Isopropoxy Salicylaldehyde 、 四氢呋喃 在 氩 、 乙基氯化镁 、 水 作用下， 反应 0.61h， 以to yield [4] (1.4 g, quantitative yield)的产率得到ortho-isopropoxy (2'-hydroxypropyl)benzene
  参考文献：
  名称：

  Chelating Carbene Ligand Precursors and Their Use in the Synthesis of Metathesis Catalysts

  摘要：

  本发明揭示了用于制备烯烃环烷化催化剂的螯合配体前体。由此产生的催化剂是空气稳定的单体物种，能够有效促进各种环烷化反应，并可以从反应混合物中回收和重复使用。内部烯烃化合物，特别是β-取代苯乙烯，被用作配体前体。与未取代的苯乙烯等末端烯烃化合物相比，β-取代苯乙烯更容易且成本更低，而且更稳定，因为它们不易自发聚合。本发明揭示了无需使用CuCl制备螯合-卡宾环烷化催化剂的方法。这通过用有机酸、矿物酸、温和氧化剂甚至水来取代CuCl，从而得到高产量的Hoveyda型环烷化催化剂。本发明提供了一种有效的方法，通过在大量的配体前体中反应适当的钌配合物复合物，然后从有机溶剂中结晶来制备螯合-卡宾环烷化催化剂。

  公开号：

  US20150018559A1

文献信息

• Chelating carbene ligand precursors and their use in the synthesis of metathesis catalysts
  申请人：Materia, Inc.

  公开号：US09504997B2

  公开（公告）日：2016-11-29

  Chelating ligand precursors for the preparation of olefin methathesis catalysts are disclosed. The resulting catalysts are air stable monomeric species capable of promoting various methathesis reactions efficiently, which can be recovered from the reaction mixture and reused. Internal olefin compounds, specifically beta-substituted styrenes, are used as ligand precursors. Compared to terminal olefin compounds such as unsubstituted styrenes, the beta-substituted styrenes are easier and less costly to prepare, and more stable since they are less prone to spontaneous polymerization. Methods of preparing chelating-carbene methathesis catalysts without the use of CuCl are disclosed. This eliminates the need for CuCl by replacing it with organic acids, mineral acids, mild oxidants or even water, resulting in high yields of Hoveyda-type methathesis catalysts. The invention provides an efficient method for preparing chelating-carbene metathesis catalysts by reacting a suitable ruthenium complex in high concentrations of the ligand precursors followed by crystallization from an organic solvent.

  用于制备烯烃甲硫醇催化剂的螯合配体前体已被披露。所得的催化剂是空气稳定的单体物种，能够有效促进各种甲硫醇反应，并且可以从反应混合物中回收并重复使用。内部烯烃化合物，特别是β-取代苯乙烯，被用作配体前体。与未取代苯乙烯等末端烯烃化合物相比，β-取代苯乙烯更容易、成本更低，并且更稳定，因为它们不太容易自发聚合。披露了一种无需使用CuCl制备螯合-卡宾甲硫醇催化剂的方法。通过用有机酸、矿酸、温和氧化剂甚至水替换CuCl，从而消除了对CuCl的需求，从而得到高产率的Hoveyda型甲硫醇催化剂。该发明提供了一种有效的方法，通过在高浓度的配体前体中反应适当的钌配合物，然后从有机溶剂中结晶，制备螯合-卡宾甲硫醇催化剂。
• US7026495B1
  申请人：——

  公开号：US7026495B1

  公开（公告）日：2006-04-11
• CHELATING CARBENE LIGAND PRECURSORS AND THEIR USE IN THE SYNTHESIS OF METATHESIS CATALYSTS
  申请人：——

  公开号：US20030166955A1

  公开（公告）日：2003-09-04

  Chelating ligand precursors for the preparation of olefin metathesis catalysts are disclosed. The resulting catalysts are air stable monomeric species capable of promoting various metathesis reactions efficiently, which can be recovered from the reaction mixture and reused. Internal olefin compounds, specifically beta-substituted styrenes, are used as ligand precursors. Compared to terminal olefin compounds such as unsubstituted styrenes, the beta-substituted styrenes are easier and less costly to prepare, and more stable since they are less prone to spontaneous polymerization. Methods of preparing chelating-carbene metathesis catalysts without the use of CuCl are disclosed. This eliminates the need for CuCl by replacing it with organic acids, mineral acids, mild oxidants or even water, resulting in high yields of Hoveyda-type metathesis catalysts. The invention provides an efficient method for preparing chelating-carbene metathesis catalysts by reacting a suitable ruthenium complex in high concentrations of the ligand precursors followed by crystallization from an organic solvent.

  揭示了用于制备烯烃转化催化剂的螯合配体前体。所得的催化剂是空气稳定的单体物种，能够高效促进各种转化反应，并可从反应混合物中回收并重复使用。内部烯烃化合物，特别是β-取代苯乙烯，被用作配体前体。与未取代苯乙烯等末端烯烃化合物相比，β-取代苯乙烯更容易、成本更低，并且更稳定，因为它们不太容易自发聚合。揭示了一种无需使用CuCl制备螯合-卡宾转化催化剂的方法。通过用有机酸、矿酸、温和氧化剂甚至水替代CuCl，从而获得高产率的Hoveyda型转化催化剂，从而消除了对CuCl的需求。该发明提供了一种有效的方法，通过在高浓度的配体前体中与适当的钌配合物反应，然后从有机溶剂中结晶，制备螯合-卡宾转化催化剂。
• Chelating Carbene Ligand Precursors and Their Use in the Synthesis of Metathesis Catalysts
  申请人：Pederson Richard L.

  公开号：US20150018559A1

  公开（公告）日：2015-01-15

  Chelating ligand precursors for the preparation of olefin methathesis catalysts are disclosed. The resulting catalysts are air stable monomeric species capable of promoting various methathesis reactions efficiently, which can be recovered from the reaction mixture and reused. Internal olefin compounds, specifically beta-substituted styrenes, are used as ligand precursors. Compared to terminal olefin compounds such as unsubstituted styrenes, the beta-substituted styrenes are easier and less costly to prepare, and more stable since they are less prone to spontaneous polymerization. Methods of preparing chelating-carbene methathesis catalysts without the use of CuCl are disclosed. This eliminates the need for CuCl by replacing it with organic acids, mineral acids, mild oxidants or even water, resulting in high yields of Hoveyda-type methathesis catalysts. The invention provides an efficient method for preparing chelating-carbene metathesis catalysts by reacting a suitable ruthenium complex in high concentrations of the ligand precursors followed by crystallization from an organic solvent.

  本发明揭示了用于制备烯烃环烷化催化剂的螯合配体前体。由此产生的催化剂是空气稳定的单体物种，能够有效促进各种环烷化反应，并可以从反应混合物中回收和重复使用。内部烯烃化合物，特别是β-取代苯乙烯，被用作配体前体。与未取代的苯乙烯等末端烯烃化合物相比，β-取代苯乙烯更容易且成本更低，而且更稳定，因为它们不易自发聚合。本发明揭示了无需使用CuCl制备螯合-卡宾环烷化催化剂的方法。这通过用有机酸、矿物酸、温和氧化剂甚至水来取代CuCl，从而得到高产量的Hoveyda型环烷化催化剂。本发明提供了一种有效的方法，通过在大量的配体前体中反应适当的钌配合物复合物，然后从有机溶剂中结晶来制备螯合-卡宾环烷化催化剂。