tetramethyl 3,3',3'',3'''-(propane-1,3-diylbis(azanetriyl))tetrapropanoate | 91933-35-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tetramethyl 3,3',3'',3'''-(propane-1,3-diylbis(azanetriyl))tetrapropanoate
• 英文别名: Methyl 3-[3-[bis(3-methoxy-3-oxopropyl)amino]propyl-(3-methoxy-3-oxopropyl)amino]propanoate
• CAS: 91933-35-6
• 化学式: C₁₉H₃₄N₂O₈
• 分子量: 418.488
• InChiKey: ACTMQRHSDGBXEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  29
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  112
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  四甲基哌啶醇 、 tetramethyl 3,3',3'',3'''-(propane-1,3-diylbis(azanetriyl))tetrapropanoate 在 titanium(IV) isopropylate 作用下， 以 正辛烷 为溶剂， 反应 7.0h， 以92.4%的产率得到tetrakis(2,2,6,6-tetramethylpiperidin-4-yl) 3,3',3'',3'''-(propane-1,3-diylbis(azanetriyl))tetrapropanoate
  参考文献：
  名称：

  一系列受阻哌啶衍生物的合成及光稳定能力

  摘要：

  摘要 以二胺、丙烯酸甲酯和2,2,6,6-五甲基-哌啶-4-醇为原料，通过迈克尔加成和酯交换反应，设计并合成了一系列含有四个受阻胺基团的新型受阻胺光稳定剂（HALS）。目标化合物的结构经1H NMR和13C NMR确证。选择其中两种用于评估其抗氧化和抗老化性能，并与聚丙烯 (PP) 和聚乙烯 (PE) 中的 HALS tinuvin 770、chimassorb 944、tinuvin 622、抗氧化剂 irganox B215 和 irganox B225 进行比较，并得出结果表明它们的抗氧化性和光稳定效率优于 HALS tinuvin 770、chimassorb 944、rinuvin 622 和抗氧化剂 irganox B215。图形概要

  DOI：

  10.1080/00397911.2010.540693
• 作为产物：
  描述：

  1,3-丙二胺 、 丙烯酸甲酯（MA） 以 乙醇 为溶剂， 反应 24.0h， 生成 tetramethyl 3,3',3'',3'''-(propane-1,3-diylbis(azanetriyl))tetrapropanoate
  参考文献：
  名称：

  基于树枝状结构的水溶性超支化共聚物，用于中低渗透性储层†

  摘要：

  在这项研究中，制备了由1,3-丙二胺为起始核的改性树枝状官能单体（称为DA），并用于与丙烯酰胺（AM），丙烯酸酯（AA）和2-丙烯酰胺基-2-甲基丙烷磺酸反应酸（AMPS）通过氧化还原自由基聚合策略合成用于中低渗透性储层的水溶性超支化共聚物（记为HPDA）。通过一系列实验对共聚物进行了表征，包括IR，11 H NMR，DLS和AFM。可以预料到的是，HPDA溶液在溶液中显示出独特的拓扑结构，与线性聚合物相比，平均直径较小。此外，对HPDA的流变性能和抗剪切性能进行了研究，结果表明，引入的树枝状结构可以在相对较高的频率范围内赋予聚合物很大的粘度保持性和优异的弹性。根据填砂管位移实验，在渗透率范围为500〜100 mD时，剪切的HPDA尺寸与孔喉之间存在良好的匹配关系。此外，与线性聚合物AM / AA / AMPS相比，剪切后的HPDA溶液为2000 mg L -1 通过控制驱替相的迁移率并在500和260

  DOI：

  10.1039/c6ra06397g

文献信息

• AMIDO-AMINE POLYMER COMPOSITIONS
  申请人：Dhal Pradeep K.

  公开号：US20100093857A1

  公开（公告）日：2010-04-15

  Compounds, polymers, crosslinked polymers and pharmaceutical compositions comprising the same may be derived from multi-amine monomers and multi-functional monomers having two or more amine reactive groups. Such compounds, polymers, crosslinked polymers and compositions may be used to treat hyperphosphatemia or to remove ions from the gastrointestinal tract of animals, including humans.
• AMIDO-AMINE DENDRIMER COMPOSITIONS
  申请人：Dhal Pradeep K.

  公开号：US20100166696A1

  公开（公告）日：2010-07-01

  Amide compounds, amide polymers and compositions, including amide compounds and amide polymers, may be used to bind target ions, such as phosphorous-containing compounds in the gastrointestinal tract of animals. In some cases, the amide polymers may be amido-amine dendrimers that may be formed via a series of iterative reactions.
• Amine-containing lipids and uses thereof
  申请人：Anderson Daniel G.

  公开号：US20110009641A1

  公开（公告）日：2011-01-13

  Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
• THERAPEUTIC COMPOSITIONS
  申请人：Tzianabos Arthur

  公开号：US20110052673A1

  公开（公告）日：2011-03-03

  Therapeutic compositions containing therapeutic agents and nitrogen-containing lipids are described. These tertiary amine-containing polymers are preferably biodegradable and biocompatible. Nanoparticles, microparticles, and complexes containing lipid/therapeutic agent complexes are also described.
• AMINE-CONTAINING LIPIDS AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20160009657A1

  公开（公告）日：2016-01-14

  Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.