3-(Azidomethyl)-2-oxaspiro[4.5]decan-1-one | 1161436-27-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 3-(Azidomethyl)-2-oxaspiro[4.5]decan-1-one
• CAS: 1161436-27-6
• 化学式: C₁₀H₁₅N₃O₂
• 分子量: 209.248
• InChiKey: RFPYEDWYXKSQFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  40.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-chloromethyl-2-oxaspiro[4.5]decan-1-one 在 sodium azide 、 sodium iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成 3-(Azidomethyl)-2-oxaspiro[4.5]decan-1-one
  参考文献：
  名称：

  ALPHA-AMINO-N-SUBSTITUTED AMIDES, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND USES THEREOF

  摘要：

  公开号：

  EP2233467B1

文献信息

• Alpha-Amino-N-Substituted Amides, Pharmaceutical Composition Containing Them and Uses Thereof
  申请人：Nan Fajun

  公开号：US20110021624A1

  公开（公告）日：2011-01-27

  Disclosed are a series of α-amino-N-substituted amide compounds having a structure of the following formula, the pharmaceutically acceptable salts thereof, and the pharmaceutical composition comprising the same. The α-amino-N-substituted amide compounds or the pharmaceutically acceptable salts thereof according to the present invention have anti-tumor and/or anti-cancer activities in vivo and in vitro, can effectively depress the growth of various tumor cells and/or cancer cells, and thus can be used in preparing drugs for treating tumors and/or cancers.
• US8470763B2
  申请人：——

  公开号：US8470763B2

  公开（公告）日：2013-06-25
• ALPHA-AMINO-N-SUBSTITUTED AMIDES, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND USES THEREOF
  申请人：SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

  公开号：EP2233467B1

  公开（公告）日：2012-09-19